Increased Transmissibility of the SARS-CoV-2 Alpha Variant in a Japanese Population.
Increased Transmissibility of the SARS-CoV-2 Alpha Variant in a Japanese Population.
复制标题
DOI：
10.3390/ijerph18157752
复制
发表时间：
2021-07-22
影响因子：
--
通讯作者：
Ogata T
中科院分区：
文献类型：
--
作者：
Tanaka H;Hirayama A;Nagai H;Shirai C;Takahashi Y;Shinomiya H;Taniguchi C;Ogata T
为了评估SARS-CoV-2Alpha变种与日本现有的SARS-CoV-2相比的相对传播性，我们进行了一项横断面研究，以确定在Alpha变种在大阪占据主导地位之前和之后家庭接触者中新冠肺炎的二次发病率。我们访问了290名家庭接触者，他们的指标病例是在2020年12月1日至20日(第三个流行组)被诊断出来的，当时大阪没有阿尔法变种。我们还访问了398名家庭接触者，他们的指示病例是在2021年4月20日至5月3日(第四个流行组)被诊断出来的，到那时阿尔法变种已经成为主导。在第四组中，我们确定了124名家庭接触者，他们的指标病例被确定为阿尔法变异阳性(阿尔法组)。第四组(34.7%)和阿尔法组(38.7%)的二次发作率显著高于第三组(19.3%，p<；0.001)。具有稳健误差方差的多变量Poisson回归分析显示，第4组(1.90，95%CI=1.47-2.48)和Alpha组(2.34，95%CI=1.71-3.21)存在显著的超额风险。这一发现表明，SARS-CoV-2 Alpha变种在日本人群中的传播率大约是先前存在的病毒的1.9-2.3倍。
To assess the relative transmissibility of the SARS-CoV-2 Alpha variant compared to the pre-existing SARS-CoV-2 in Japan, we performed a cross-sectional study to determine the secondary attack rate of COVID-19 in household contacts before and after the Alpha variant became dominant in Osaka. We accessed 290 household contacts whose index cases were diagnosed between 1 and 20 December 2020 (the third epidemic group), at a time when Osaka was free of the Alpha variant. We also accessed 398 household contacts whose index cases were diagnosed between 20 April and 3 May 2021 (the fourth epidemic group), by which time the Alpha variant had become dominant. We identified 124 household contacts whose index case was determined positive for the Alpha variant (Alpha group) in this fourth group. The secondary attack rates in the fourth group (34.7%) and the Alpha group (38.7%) were significantly higher than that in the third group (19.3%, p < 0.001). Multivariable Poisson regression analysis with a robust error variance showed a significant excess risk in the fourth group (1.90, 95% CI = 1.47–2.48) and the Alpha group (2.34, 95% CI = 1.71–3.21). This finding indicates that the SARS-CoV-2 Alpha variant has an approximately 1.9–2.3-fold higher transmissibility than the pre-existing virus in the Japanese population.
登录
查看更多内容
DOI：
10.1016/s2468-2667(21)00055-4
发表时间：
2021-05
期刊：
The Lancet. Public health
影响因子：
--
作者：
Graham MS;Sudre CH;May A;Antonelli M;Murray B;Varsavsky T;Kläser K;Canas LS;Molteni E;Modat M;Drew DA;Nguyen LH;Polidori L;Selvachandran S;Hu C;Capdevila J;COVID-19 Genomics UK (COG-UK) Consortium;Hammers A;Chan AT;Wolf J;Spector TD;Steves CJ;Ourselin S
通讯作者：
Ourselin S
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
案例对照研究对泰国SARS-COV 2感染的个人保护措施的使用和风险。
影响因子：
11.8
作者：
Doung-Ngern P;Suphanchaimat R;Panjangampatthana A;Janekrongtham C;Ruampoom D;Daochaeng N;Eungkanit N;Pisitpayat N;Srisong N;Yasopa O;Plernprom P;Promduangsi P;Kumphon P;Suangtho P;Watakulsin P;Chaiya S;Kripattanapong S;Chantian T;Bloss E;Namwat C;Limmathurotsakul D
通讯作者：
Limmathurotsakul D
DOI：
10.2807/1560-7917.es.2020.26.1.2002106
发表时间：
2021-01
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Leung K;Shum MH;Leung GM;Lam TT;Wu JT
通讯作者：
Wu JT
影响因子：
64.8
作者：
Volz, Erik;Mishra, Swapnil;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.