Halogen-Induced Controllable Cyclizations as Diverse Heterocycle Synthetic Strategy.
Halogen-Induced Controllable Cyclizations as Diverse Heterocycle Synthetic Strategy.
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DOI：
10.3390/molecules25246007
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发表时间：
2020-12-18
期刊：
影响因子：
--
通讯作者：
Dohi T
中科院分区：
文献类型：
--
作者：
China H;Kumar R;Kikushima K;Dohi T
在有机合成中，由于它们的高亲电性和离去基团性质，卤素在有机化合物的活化和结构衍生中起着关键作用。最近，卤素基团诱导的环化反应，允许生产不同的目标和有机分子的结构重组引起了合成化学家的极大关注。亲电卤素原子通过生成卤中间体活化不饱和和饱和烃部分，然后通过含碳、含氮、含氧和含硫亲核试剂的攻击得到高度官能化的碳环和杂环。最近发现了卤代有机分子的新的转变，其可以根据卤原子的大小和数量的差异来控制产物的形成和立体选择性。这些独特的环化反应有可能作为未来发展的有效合成策略。本文综述了有机合成领域中的一个新概念--卤素基团控制的创新反应。
In organic synthesis, due to their high electrophilicity and leaving group properties, halogens play pivotal roles in the activation and structural derivations of organic compounds. Recently, cyclizations induced by halogen groups that allow the production of diverse targets and the structural reorganization of organic molecules have attracted significant attention from synthetic chemists. Electrophilic halogen atoms activate unsaturated and saturated hydrocarbon moieties by generating halonium intermediates, followed by the attack of carbon-containing, nitrogen-containing, oxygen-containing, and sulfur-containing nucleophiles to give highly functionalized carbocycles and heterocycles. New transformations of halogenated organic molecules that can control the formation and stereoselectivity of the products, according to the difference in the size and number of halogen atoms, have recently been discovered. These unique cyclizations may possibly be used as efficient synthetic strategies with future advances. In this review, innovative reactions controlled by halogen groups are discussed as a new concept in the field of organic synthesis.
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影响因子：
6.6
作者：
Gieuw, Matthew H.;Ke, Zhihai;Yeung, Ying-Yeung
通讯作者：
Yeung, Ying-Yeung
DOI：
10.1073/pnas.1005296107
发表时间：
2010-11-30
影响因子：
11.1
作者：
Denmark, Scott E.;Burk, Matthew T.
通讯作者：
Burk, Matthew T.
烯烃的催化、不对称卤代官能化——一个批判的视角。
DOI：
10.1002/anie.201204347
发表时间：
2012-10-29
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Denmark SE;Kuester WE;Burk MT
通讯作者：
Burk MT
影响因子：
1.8
作者：
ALANINE, AID;FISHWICK, CWG;SZANTAY, C
通讯作者：
SZANTAY, C
影响因子：
1.8
作者：
BALKO, TW;BRINKMEYER, RS;TERANDO, NH
通讯作者：
TERANDO, NH