Association between healthy lifestyle and the occurrence of cardiometabolic multimorbidity in hypertensive patients: a prospective cohort study of UK Biobank.
Association between healthy lifestyle and the occurrence of cardiometabolic multimorbidity in hypertensive patients: a prospective cohort study of UK Biobank.
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DOI：
10.1186/s12933-022-01632-3
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发表时间：
2022-10-01
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
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作者：
高血压患者中心脏代谢性多瘤（CMM）越来越常见，健康的生活方式在预防高血压中起着关键作用。然而，在高血压患者中，生活方式因素与CMM之间的关联尚不确定。这项前瞻性分析包括没有冠心病（CHD）、中风或糖尿病的高血压患者的数据（从英国生物库获得）。结果是CMM的发生率，定义为在高血压参与者中发生≥ 1种CHD、卒中和糖尿病疾病。使用加权健康生活方式评分评估了四种生活方式因素（吸烟，饮酒，饮食和体育活动），并将参与者分为四组：非常不健康，不健康，健康和非常健康组。灵活的参数Royston-Parmar比例风险模型用于估计生活方式和CMM之间的风险比（HR），以及无CMM预期寿命的差异。在中位随访12.2年期间，53，397例高血压患者中有9812例（18.4%）发生CMM。与非常不健康组相比，非常健康组的高血压患者中CMM的风险降低了41%，特定心脏代谢疾病（如CHD，中风和糖尿病）的风险降低了32-50%。对于每个生活方式因素，不吸烟对CMM的保护作用最大（HR：0.64，95%置信区间（CI）0.60-0.68）。结合多种健康因素的生活方式延长了无CMM的预期寿命（例如，对于非常健康组的参与者，在45岁时长6年）。健康的生活方式因素与高血压患者中CMM的低风险相关。这表明，应支持组合健康的生活方式，以减少疾病负担。在线版本包含补充材料，可通过10.1186/s12933-022-01632-3获得。
Cardiometabolic multimorbidity (CMM) is becoming increasingly common in patients with hypertension, and it is well established that healthy lifestyle plays a key role in the prevention of hypertension. However, the association between combined lifestyle factors and CMM in patients with hypertension is uncertain. This prospective analysis included the data (obtained from the UK biobank) of participants with hypertension who did not have coronary heart disease (CHD), stroke, or diabetes. The outcome was the occurrence of CMM, defined as ≥ 1 disease of CHD, stroke, and diabetes that occurred in participants with hypertension. Four lifestyle factors (smoking, alcohol consumption, diet, and physical activity) were assessed using a weighted healthy lifestyle score, and participants were divided into four groups: the very unhealthy, unhealthy, healthy, and very healthy groups. The flexible parameter Royston-Parmar proportional hazard model was used to estimate hazard ratios (HRs) between lifestyles and CMM, as well as the difference in CMM-free life expectancy. During a median follow-up of 12.2 years, 9812 (18.4%) of the 53,397 hypertensive patients occurred CMM. Compared with the very unhealthy group, the very healthy group had a 41% reduction in the risk for CMM in hypertensive patients and a 32–50% reduction in the risk for specific cardiometabolic diseases such as CHD, stroke, and diabetes. For each lifestyle factor, non-smoking had the greatest protective effect against CMM (HR: 0.64, 95% confidence interval (CI) 0.60–0.68). A lifestyle combining multiple healthy factors extended CMM-free life expectancy (e.g., six years longer at age 45 years for participants in the very healthy group). Combined healthy lifestyle factors were associated with a lower risk for CMM in hypertensive patients. This suggests that combined healthy lifestyle should be supported to decrease disease burden. The online version contains supplementary material available at 10.1186/s12933-022-01632-3.
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DOI：
10.1136/bmj.j2250
发表时间：
2017-05-25
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Dehbi HM;Royston P;Hackshaw A
通讯作者：
Hackshaw A
影响因子：
4.8
作者：
Alaba, Olufunke;Chola, Lumbwe
通讯作者：
Chola, Lumbwe
影响因子：
6.3
作者：
Jung, Sukyoung;Kim, Mi Kyung;Lee, Young-Hoon
通讯作者：
Lee, Young-Hoon
影响因子：
3.8
作者：
Aminisani, Nayyereh;Stephens, Christine;Shamshirgaran, Seyed Morteza
通讯作者：
Shamshirgaran, Seyed Morteza
影响因子：
3.8
作者：
King BM
通讯作者：
King BM