Clinical and laboratory investigation of allergy to genetically modified foods.
Clinical and laboratory investigation of allergy to genetically modified foods.
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转基因食品过敏的临床和实验室调查。
DOI：
--
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发表时间：
2002
影响因子：
10.4
通讯作者：
Bloomberg
中科院分区：
文献类型：
--
作者：
Jonathan A. Bernstein;I. L. Bernstein;L. Bucchini;L. Goldman;Robert G Hamilton;S. Lehrer;C. Rubin;Hugh A. Sampson;L. Goldman;Bloomberg
自首次种植农作物以来，技术已经改善了食品供应。基因工程促进了生物之间的基因转移。一般来说，只需表达微量的特定蛋白质就能获得所需的性状。食物过敏只影响对食物有异常免疫反应的个体——在美国，6%的儿童和1.5 - 2%的成年人受此影响。并非所有由食物过敏引起的疾病都是由免疫球蛋白E（IgE）介导的。许多专家委员会就食物蛋白质过敏性的风险评估向美国政府和国际组织提供了建议。这些委员会主要基于对IgE介导的食物过敏性的评估制定了决策树。困难包括：来自过敏者的过敏原特异性IgE抗血清作为经过验证的源材料供应有限，特异性IgE检测的实用性，食物蛋白质特性描述有限，食物与其他过敏原之间的交叉反应，以及加工过程中食物蛋白质的改性。“星联”是一种经过改良的玉米品种，可产生苏云金芽孢杆菌（Bt）内毒素Cry9C。美国疾病控制与预防中心调查了51份在宣布用于动物饲料的“星联”玉米出现在人类食品供应中之后可能出现的对玉米不良反应的报告。过敏反应未得到证实，但上市后评估的工具有限。农业和食品加工设施的工人有可能吸入植物粉尘和面粉。1999年，研究人员发现，流动医疗工作者在接触Bt喷雾后可能会对某些Bt孢子提取物产生过敏反应。
Technology has improved the food supply since the first cultivation of crops. Genetic engineering facilitates the transfer of genes among organisms. Generally, only minute amounts of a specific protein need to be expressed to obtain the desired trait. Food allergy affects only individuals with an abnormal immunologic response to food--6% of children and 1.5-2% of adults in the United States. Not all diseases caused by food allergy are mediated by IgE. A number of expert committees have advised the U.S. government and international organizations on risk assessment for allergenicity of food proteins. These committees have created decision trees largely based on assessment of IgE-mediated food allergenicity. Difficulties include the limited availability of allergen-specific IgE antisera from allergic persons as validated source material, the utility of specific IgE assays, limited characterization of food proteins, cross-reactivity between food and other allergens, and modifications of food proteins by processing. StarLink was a corn variety modified to produce a (Italic)Bacillus thuringiensis(/Italic) (Bt) endotoxin, Cry9C. The Centers for Disease Control and Prevention investigated 51 reports of possible adverse reactions to corn that occurred after the announcement that StarLink, allowed for animal feed, was found in the human food supply. Allergic reactions were not confirmed, but tools for postmarket assessment were limited. Workers in agricultural and food preparation facilities have potential inhalation exposure to plant dusts and flours. In 1999, researchers found that migrant health workers can become sensitized to certain Bt spore extracts after exposure to Bt spraying.
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简介：解决转基因食品潜在致敏性的问题有哪些？
影响因子：
10.4
作者：
Metcalfe,DeanD
通讯作者：
Metcalfe,DeanD
DOI：
10.1001/jama.1988.03410100140041
发表时间：
1988-09
期刊：
JAMA
影响因子：
--
作者：
J. Yunginger;K. G. Sweeney;W. Sturner;Leigh A. Giannandrea;J. D. Teigland;Michael Bray;Peter A. Benson;James A. York;L. Biedrzycki;D. Squillace;R. Helm
通讯作者：
J. Yunginger;K. G. Sweeney;W. Sturner;Leigh A. Giannandrea;J. D. Teigland;Michael Bray;Peter A. Benson;James A. York;L. Biedrzycki;D. Squillace;R. Helm
吸入和摄入大蒜诱发的职业性哮喘。
DOI：
10.1016/0091-6749(82)90120-8
发表时间：
1982
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Lybarger,JA;Gallagher,JS;Pulver,DW;Litwin,A;Brooks,S;Bernstein,IL
通讯作者：
Bernstein,IL
影响因子：
158.5
作者：
SAMPSON, HA;MENDELSON, L;ROSEN, JP
通讯作者：
ROSEN, JP
影响因子：
14.2
作者：
Sampson, HA
通讯作者：
Sampson, HA