Dopaminergic modulation of the planning phase of skill acquisition in Parkinson's disease.
Dopaminergic modulation of the planning phase of skill acquisition in Parkinson's disease.
复制标题
帕金森氏病技能获取计划阶段的多巴胺能调节。
DOI：
10.1080/13554790903379609
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发表时间：
2010-04
期刊：
影响因子：
0.8
通讯作者：
Heilman KM
中科院分区：
文献类型：
--
作者：
Hanna-Pladdy B;Heilman KM
帕金森氏病(PD)患者在执行运动动作和获得新的运动技能时经常受到损害。然而，多巴胺在制定技能获得计划方面的作用尚不清楚。为了评估多巴胺在行动计划中的作用，我们测试了12名帕金森病患者和12名匹配的正常参与者在两项技能获取任务中的情况，这两项任务与运动需求相匹配，但对计划的要求不同。帕金森病参与者在服用和停用多巴胺能药物时进行了这些任务的测试。为了最大限度地减少运动相关缺陷的影响，受试者使用了计算机轨迹指示器，当受试者施加轻微的力并点击轨迹指示器以启动和终止每条线段时，该指示器会产生所需的直线。轨迹指针偏转的时间量决定了线的长度，而点击鼠标则决定了线的位置。简单图形复制任务只要求被试重复生成两种尺寸的线条，而复杂图形复制任务要求被试生成不同尺寸的线条。因此，这项复杂的任务需要更多的预见性计划。与对照组相比，帕金森病患者学习生成这些图形所需的程序的速度较慢，并且在简单和复杂任务中生成的图形幅度都有所降低。然而，多巴胺治疗只提高了复杂任务中图形完成的速度，这表明多巴胺在行动计划中很重要。
Patients with Parkinson’s disease (PD) are often impaired when performing motor acts and in the acquisition of new motor skills. However, the role of dopamine in developing plans for skill acquisition is unclear. To assess the role of dopamine on the planning of actions, we tested 12 PD and 12 matched normal participants on two skill acquisition tasks matched for motor demands, but varying in requirements for planning. The participants with PD were tested on these tasks when they were on and off dopaminergic medications. To minimize influence of movement related deficits, the subjects used a computer track-pointer that generated the required straight lines when the subjects applied a slight force and clicked the track-pointer to initiate and terminate each line segment. The amount of time the track-pointer was deflected determined the line lengths, while clicking of the mouse determined the location of the line. The simple figure replication task only required the subjects to repeatedly generate lines of two sizes, while the complex figure replication task required subjects to generate lines of different sizes. Thus, this complex task demanded more anticipatory planning. Compared to controls, the subjects with PD were slower to learn the programs needed to produce these figures and produced figures with reduced amplitudes on both the simple and complex tasks. Dopamine treatment, however, only improved the speed of figure completion on the complex task, suggesting that dopamine is important in action planning.
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影响因子：
14.5
作者：
BENECKE, R;ROTHWELL, JC;MARSDEN, CD
通讯作者：
MARSDEN, CD
影响因子：
14.5
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Majsak, MJ;Kaminski, T;Flanagan, JR
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2
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影响因子：
14.5
作者：
GEORGIOU, N;IANSEK, R;BRADSHAW, JA
通讯作者：
BRADSHAW, JA