Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling.
Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling.
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DOI：
10.1016/j.stem.2010.05.019
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发表时间：
2010-08-06
期刊：
影响因子：
23.9
通讯作者：
Temple S
中科院分区：
文献类型：
--
作者：
Kokovay E;Goderie S;Wang Y;Lotz S;Lin G;Sun Y;Roysam B;Shen Q;Temple S
成人室下区（SVZ）的神经祖细胞（npc）与室管膜和血管壁龛有关，这些壁龛调节干细胞的自我更新和分化。活化的B型干细胞及其后代，即表达EGFR的转运扩增型C型细胞，与血管细胞高度相关，表明这一生态位支持谱系进展。本研究表明，增殖性SVZ祖细胞以基质衍生因子1 （SDF1）和CXC趋化因子受体4 （CXCR4）依赖的方式归巢内皮细胞。我们发现，在活化的B型和C型细胞中，SDF1强烈上调EGFR和α6整合素，增强了它们的激活状态，并增强了它们在血管生态位中结合层粘连蛋白的能力。SDF1增加了A型神经母细胞的运动性，使其从SVZ向嗅球迁移。因此，对SDF1的差异反应可以调节成年SVZ血管生态位的祖细胞占用和退出。
Neural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are associated with ependymal and vasculature niches which regulate stem cell self-renewal and differentiation. Activated Type B stem cells and their progeny, the transit amplifying Type C cells, which express EGFR, are most highly associated with vascular cells, indicating that this niche supports lineage progression. Here we show that proliferative SVZ progenitor cells home to endothelial cells in a stromal-derived factor 1 (SDF1) and CXC chemokine receptor 4 (CXCR4) dependent manner. We show that SDF1 strongly upregulates EGFR and α6 integrin in activated type B and type C cells, enhancing their activated state and their ability to bind laminin in the vascular niche. SDF1 increases the motility of Type A neuroblasts, which migrate from the SVZ towards the olfactory bulb. Thus, differential responses to SDF1 can regulate progenitor cell occupancy of and exit from the adult SVZ vascular niche.
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DOI：
10.1634/stemcells.2008-0519
发表时间：
2008-12
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Barkho BZ;Munoz AE;Li X;Li L;Cunningham LA;Zhao X
通讯作者：
Zhao X
影响因子：
5.3
作者：
Bovetti, Serena;Hsieh, Yi-Chun;Puche, Adam C.
通讯作者：
Puche, Adam C.
影响因子：
5.8
作者：
Guo, Zhigang;Cai, Shaoxi;Liu, Yiyao
通讯作者：
Liu, Yiyao
影响因子：
2.9
作者：
Liu, Xian Shuang;Chopp, Michael;Zhang, Zheng Gang
通讯作者：
Zhang, Zheng Gang
DOI：
10.1073/pnas.95.16.9448
发表时间：
1998-08-04
影响因子：
11.1
作者：
Ma, Q;Jones, D;Springer, TA
通讯作者：
Springer, TA