Programmed cell death 1 positive lymphocytes at palate tonsils in the elder patients with chronic tonsillitis.
Programmed cell death 1 positive lymphocytes at palate tonsils in the elder patients with chronic tonsillitis.
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老年慢性扁桃体炎患者腭扁桃体程序性细胞死亡1阳性淋巴细胞的研究。
DOI：
10.1016/j.bbrep.2020.100898
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发表时间：
2021-03
影响因子：
2.7
通讯作者：
Nishiura H
中科院分区：
文献类型：
--
作者：
Fujihara Y;Yamanegi K;Nagasawa Y;Yoshida A;Goto Y;Kumanishi S;Futani H;Fukunishi S;Yoshiya S;Nishiura H
循环淋巴细胞在急性伤口愈合的炎症期浸润到局部病灶，激活免疫系统，在消退期表达免疫检查点蛋白程序性细胞死亡1 (PD-1)，使免疫系统失活。相反，老年慢性扁桃体炎患者在姑息期的循环淋巴细胞中仍有PD-1的表达。最近，一种粘附G蛋白偶联受体56 （GPR56）被报道至少在急性伤口愈合的消退阶段作为浸润淋巴细胞进入局部病灶的增殖因子。为了初步研究PD-1和GPR56在慢性炎症局部病灶中的类似作用，我们从少量慢性扁桃体炎和扁桃体肥大患者中制备了腭扁桃体。在老年慢性扁桃体炎患者中，PD-1与GPR56的RNA表达可能呈正相关。免疫组织病理学结果显示，慢性扁桃体炎患者扁桃体淋巴滤泡边缘区有大量或少量的PD-1和GPR56表达。此外，PD-1与GPR56的RNA表达正相关在大量老年慢性扁桃体炎患者中得到证实。可能，GPR56通过位于腭扁桃体淋巴滤泡边缘区的淋巴细胞维持系统参与了老年慢性扁桃体炎患者循环血液中PD-1+淋巴细胞的补充。腭扁桃体边缘区PD-1+淋巴细胞聚集。GPR56转录物在腭扁桃体的表达。GPR56+淋巴细胞与PD-1+淋巴细胞共定位。慢性扁桃体炎患者腭扁桃体GPR56与PD-1呈正相关。
Circulating lymphocytes infiltrate into local foci at the inflammatory phase of acute wound healing for activation of the immune system and express an immune checkpoint protein programmed cell death 1 (PD-1) at the resolution phase for inactivation of the immune system. Conversely, the PD-1 expression was still found even on circulating lymphocytes of the elder patients with chronic tonsillitis at the palliative stage. Recently, an adhesion G protein coupled receptor 56 (GPR56) was reported to at least work as a proliferation factor for infiltrated lymphocytes into local foci at the resolution phase of acute wound healing. To preliminary examine a similar role of PD-1 and GPR56 at local foci at chronic inflammation, palate tonsils were prepared from small amounts of patients with chronic tonsillitis and tonsillar hypertrophy. A positive relationship of RNA expression might be observed between PD-1 and GPR56 in the elder patients with chronic tonsillitis. In regard to immunohistopathological findings, there were huge and small amounts of PD-1 and GPR56 expression at the marginal zone of lymphoid follicles of palate tonsils with chronic tonsillitis. Moreover, the positive relationship of RNA expression between PD-1 and GPR56 confirmed in large numbers of the elder patients with chronic tonsillitis. Probably, GPR56 participates in a supplement of PD-1+ lymphocytes to circulating bloods of the elder patients with chronic tonsillitis through a lymphocyte cell maintenance system at the marginal zone of the lymphoid follicles of palate tonsils. Accumulation of PD-1+ lymphocytes at the marginal zone of palate tonsils. Expression of GPR56 transcript at palate tonsils. Co-localization of GPR56+ lymphocytes besides PD-1+ lymphocytes. Positive relationship between GPR56 and PD-1 in palate tonsils of chronic tonsillitis-patients.
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影响因子：
29.7
作者：
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通讯作者：
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影响因子：
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作者：
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期刊：
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影响因子：
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