Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis.
Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis.
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DOI：
10.1002/art.40504
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Buckley CD
中科院分区：
文献类型：
--
作者：
Falconer J;Murphy AN;Young SP;Clark AR;Tiziani S;Guma M;Buckley CD
体液代谢组学研究表明，免疫介导的炎症性疾病，如类风湿性关节炎（RA）与代谢紊乱有关。这可能反映了持续炎症的生物能量和生物合成需求增加以及受损组织中营养和氧气可用性的变化。滑膜衬里层是类风湿关节炎的主要炎症部位。在这里，常驻细胞是成纤维细胞样滑膜细胞（FLS）和滑膜组织巨噬细胞（STM），它们被转化为过度产生降解软骨和骨的酶以及促进免疫细胞浸润的细胞因子。最近的研究表明，RA患者的FLS和巨噬细胞的代谢变化，这些可能是治疗靶向的。然而，由于滑膜细胞的起源和亚群特异性功能知之甚少，控制RA滑膜细胞代谢偏离的信号传导模块尚未探索，因此需要进行更多的研究以将这些发现转化为临床应用。此外，在许多炎症组织中，不同类型的细胞可以通过其膜中的溶质载体（SLC）进行代谢合作，以满足对能量或生物分子的高需求。这种关系很可能存在于滑膜中，尚待探索。最后，目前尚不清楚代谢变化是否是疾病的结果，或者细胞代谢的主要变化是否可能是早期疾病发病机制的基础或原因。本文整理了什么是已知的代谢在滑膜组织细胞，并强调了未来的研究方向在这一领域。
Metabolomic studies of body fluids show that immune-mediated inflammatory diseases such as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect the increased bioenergetic and biosynthetic demands of sustained inflammation and changes to nutrient and oxygen availability in damaged tissue. The synovial membrane lining layer is the principle site of inflammation in RA. Here the resident cells are the fibroblast-like synoviocytes (FLS) and the synovial tissue macrophages (STM), which are transformed toward overproduction of enzymes which degrade cartilage and bone, and cytokines which promote immune cell infiltration. Recent studies have shown metabolic changes in both FLS and macrophages from RA patients and these may be therapeutically targetable. However, as the origins and subset specific functions of synoviocytes are poorly understood and the signaling modules which control metabolic deviation in RA synovial cells are yet to be explored, significant additional research is needed to translate these findings toward clinical application. Furthermore, in many inflamed tissues, different cell types can forge metabolic collaborations through solute carriers (SLC) in their membranes, to meet a high demand for energy or biomolecules. Such relationships are likely to exist in the synovium and are yet to be explored. Finally, it is not yet known whether metabolic change is a consequence of disease or if primary changes to cellular metabolism might underlie or contribute to early stage disease pathogenesis. This article collates what is known about metabolism in synovial tissue cells and highlights future research directions in this area.
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影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
影响因子：
4.9
作者：
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通讯作者：
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影响因子：
4.9
作者：
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通讯作者：
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影响因子：
7.1
作者：
Cederholm, T;Wretlind, B;Palmblad, J
通讯作者：
Palmblad, J
影响因子：
2.8
作者：
Fuchs, B;Schiller, E;Arnold, K
通讯作者：
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