Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections.
Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections.
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DOI：
10.3390/s130405130
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发表时间：
2013-04-18
期刊：
影响因子：
--
通讯作者：
Gresham H
中科院分区：
文献类型：
--
作者：
Gray B;Hall P;Gresham H
革兰氏阳性病原体金黄色葡萄球菌的侵袭性感染由四基因操纵子agr控制，agr编码用于调节毒力的群体感应系统。而agr在S.尽管agr同源物和类似物在金黄色葡萄球菌中的作用还不清楚，但对agr同源物和类似物在其它革兰氏阳性病原体中的作用的了解才刚刚开始。有趣的是，其他重要的人类病原体，包括产气荚膜梭菌，单核细胞增生李斯特菌和粪肠球菌都含有与毒力相关的agr或类似物。此外，其他重要的人类革兰氏阳性病原体使用基于肽的群体感应系统来建立或维持感染。这些信号系统在不同物种中的共性提高了鉴定可以靶向多种病原体的治疗剂的前景。在这里，我们回顾了这些agr同源物，类似物，和其他肽为基础的群体感应系统在革兰氏阳性病原体的研究现状，以及确定共同的途径和信号机制的治疗发现的潜力。
Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a four gene operon, agr that encodes a quorum sensing system for the regulation of virulence. While agr has been well studied in S. aureus, the contribution of agr homologues and analogues in other Gram-positive pathogens is just beginning to be understood. Intriguingly, other significant human pathogens, including Clostridium perfringens, Listeria monocytogenes, and Enterococcus faecalis contain agr or analogues linked to virulence. Moreover, other significant human Gram-positive pathogens use peptide based quorum sensing systems to establish or maintain infection. The potential for commonality in aspects of these signaling systems across different species raises the prospect of identifying therapeutics that could target multiple pathogens. Here, we review the status of research into these agr homologues, analogues, and other peptide based quorum sensing systems in Gram-positive pathogens as well as the potential for identifying common pathways and signaling mechanisms for therapeutic discovery.
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影响因子：
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