Managing toxicities with asparaginase-based therapies in adult ALL: summary of an ESMO Open-Cancer Horizons roundtable discussion.
Managing toxicities with asparaginase-based therapies in adult ALL: summary of an ESMO Open-Cancer Horizons roundtable discussion.
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DOI：
10.1136/esmoopen-2020-000858
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发表时间：
2020-10
期刊：
影响因子：
7.3
通讯作者：
Douer D
中科院分区：
文献类型：
--
作者：
Burke PW;Hoelzer D;Park JH;Schmiegelow K;Douer D
最近的前瞻性临床试验在成人中使用多剂量聚乙二醇化形式的天冬酰胺酶（PEG天冬酰胺酶）的儿科方案，与使用较少天冬酰胺酶的方案的历史数据相比，报告了显著改善的生存率，PEG天冬酰胺酶越来越多地用于治疗成人急性淋巴细胞白血病（ALL）。然而，施用天冬酰胺酶仍然伴随着其挑战，特别是在成人患者中。因此，了解如何正确管理其毒性非常重要。一个专家组于2019年11月在伦敦举行会议，讨论了使用儿科方案的儿科和成人研究的最新数据，这些研究涉及天冬酰胺酶治疗成人可能发生的几种关键毒性的最佳管理，包括肝毒性、胰腺炎、高脂血症、血栓形成和超敏反应。针对这些毒性中的每一种都提出了几项建议，目的是安全地使用药物，并教育临床医生尽管有副作用，何时可以继续使用药物。
With recent prospective clinical trials that used paediatric regimens with multiple doses of pegylated form of asparaginase (PEG asparaginase) in adults reporting significantly improved survival compared with historical data with regimens that used less asparaginase, PEG asparaginase is increasingly being used in the treatment of adult acute lymphoblastic leukaemia (ALL). However, administering asparaginase still comes with its challenges, especially in adult patients. Therefore, it is important to understand how to manage its toxicities properly. An expert group met in November 2019 in London to discuss recent data of paediatric as well as adult studies using paediatric regimens with regard to the best management of several key toxicities that can occur in adults treated with asparaginase including hepatotoxicity, pancreatitis, hypertriglyceridaemia, thrombosis and hypersensitivity. Several recommendations were made for each one of these toxicities, with the goal of safe administration of the drug and to educate clinicians when the drug can be continued despite side effects.
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影响因子：
45.3
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