Early-life programming of later-life brain and behavior: a critical role for the immune system.
Early-life programming of later-life brain and behavior: a critical role for the immune system.
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DOI：
10.3389/neuro.08.014.2009
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发表时间：
2009
影响因子：
3
通讯作者：
Schwarz JM
中科院分区：
文献类型：
--
作者：
Bilbo SD;Schwarz JM
免疫系统在宿主防御中的关键作用得到了很好的表征。然而，远远超出这一有限的作用，越来越多的证据表明免疫系统在大脑中，在正常的"稳态"过程（例如，睡眠、代谢、记忆），以及在病理学中，当免疫分子的失调可能发生时。这种认识在大脑发育领域尤其重要。小胶质细胞和星形胶质细胞是CNS的主要免疫活性细胞，参与脑发育和功能的每个主要方面，包括突触发生、凋亡和血管生成。肿瘤坏死因子（TNF）α、白细胞介素[IL]-1 β和IL-6等细胞因子由CNS内的神经胶质细胞产生，并参与突触形成和缩放、长时程增强和神经发生。重要的是，细胞因子参与损伤和修复，这些不同结果的基础条件正在进行激烈的研究和辩论。来自动物和人类研究的证据表明，免疫系统与许多已知或疑似发育起源的疾病有关，包括精神分裂症、焦虑/抑郁和认知功能障碍。我们回顾的证据表明，感染在围产期的生命作为一个脆弱的因素，为以后的生活中的细胞因子的生产变化，并在整个生命的其余部分的认知和情感行为的显着变化。我们还讨论了这一假设，即大脑神经胶质细胞功能的长期变化是这种脆弱性的基础。
The immune system is well characterized for its critical role in host defense. Far beyond this limited role however, there is mounting evidence for the vital role the immune system plays within the brain, in both normal, “homeostatic” processes (e.g., sleep, metabolism, memory), as well as in pathology, when the dysregulation of immune molecules may occur. This recognition is especially critical in the area of brain development. Microglia and astrocytes, the primary immunocompetent cells of the CNS, are involved in every major aspect of brain development and function, including synaptogenesis, apoptosis, and angiogenesis. Cytokines such as tumor necrosis factor (TNF)α, interleukin [IL]-1β, and IL-6 are produced by glia within the CNS, and are implicated in synaptic formation and scaling, long-term potentiation, and neurogenesis. Importantly, cytokines are involved in both injury and repair, and the conditions underlying these distinct outcomes are under intense investigation and debate. Evidence from both animal and human studies implicates the immune system in a number of disorders with known or suspected developmental origins, including schizophrenia, anxiety/depression, and cognitive dysfunction. We review the evidence that infection during the perinatal period of life acts as a vulnerability factor for later-life alterations in cytokine production, and marked changes in cognitive and affective behaviors throughout the remainder of the lifespan. We also discuss the hypothesis that long-term changes in brain glial cell function underlie this vulnerability.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
2.7
作者：
Bilbo, SD;Rudy, JW;Maier, SF
通讯作者：
Maier, SF
影响因子：
5.3
作者：
Bilbo, SD;Biedenkapp, JC;Maier, SF
通讯作者：
Maier, SF
影响因子：
7.4
作者：
Boissé, L;Spencer, SJ;Pittman, QJ
通讯作者：
Pittman, QJ
影响因子：
2.6
作者：
Bufford, JD;Gem, JE
通讯作者：
Gem, JE