Association of PON2 Gene Polymorphisms (Ser311Cys and Ala148Gly) With the Risk of Developing Type 2 Diabetes Mellitus in the Chinese Population.
Association of PON2 Gene Polymorphisms (Ser311Cys and Ala148Gly) With the Risk of Developing Type 2 Diabetes Mellitus in the Chinese Population.
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PON2 基因多态性（Ser311Cys 和 Ala148Gly）与中国人群患 2 型糖尿病风险的关联
DOI：
10.3389/fendo.2018.00495
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发表时间：
2018
影响因子：
5.2
通讯作者：
Luo JQ
中科院分区：
文献类型：
--
作者：
Ren H;Tan SL;Liu MZ;Banh HL;Luo JQ
背景：在中国人群中，对氧磷酶2(PON2)基因多态性与2型糖尿病(T2 DM)的相关性进行了广泛的研究，但结果相互矛盾。在这项研究中，我们通过综合所有相关研究，系统地评估了PON2Ser311Cys和Ala148Gly基因多态性与T2 DM风险的关系。方法：检索PubMed、Embase、CNKI和万方数据库。关联强度由等位基因、纯合子、杂合子、隐性和显性遗传模型确定，并在固定或随机效应模型下以优势比(OR)和95%可信区间(CI)来测量。结果：在等位基因(OR=1.06，95%CI=0.77~1.45；P=0.721)、杂合子(OR=1.13，95%CI=0.87~1.45；P=0.362)、显性(OR=1.10，95%CI=0.80~1.51；P=0.562)、隐性(OR=0.87，95%CI=0.48~1.58；P=0.562；P=0.648)、纯合子(OR=0.94，95%CI=0.47~1.89；P=0.865)。等位基因(OR=1.17，95%CI=0.91~1.50；P=0.218)、杂合子(OR=1.28，95%CI=0.94~1.74；P=0.117)、显性(OR=1.25，95%CI=0.93~1.67；P=0.142)、隐性(OR=0.99，95%CI=0.52~1.88)；P=0.973)、纯合子(OR=1.08，95%CI=0.57~2.07；P=0.808)。结论：PON2Ser311Cys和Ala148Gly基因多态性与中国人群T2 DM发病风险无关。
Background: The association between paraoxonase 2 (PON2) gene polymorphisms and type 2 diabetes mellitus (T2DM) has been extensively investigated in the Chinese population with conflicting results. In this study, we systematically evaluated the association between PON2 Ser311Cys and Ala148Gly polymorphisms and T2DM risk by pooling all relevant studies. Methods: We searched PubMed, Embase, CNKI, and Wanfang databases for the studies. The strength of association was determined by the allelic, homozygous, heterozygous, recessive, and dominant genetic models and measured as odds ratio (OR) and 95% confidence interval (CI), under fixed- or random-effect models. Results: There was no significant association between PON2 Ser311Cys polymorphism and T2DM under any of the genetic models: allelic (OR = 1.06, 95% CI = 0.77–1.45; P = 0.721), heterozygous (OR = 1.13, 95% CI = 0.87–1.45; P = 0.362), dominant (OR = 1.10, 95% CI = 0.80–1.51; P = 0.562), recessive (OR = 0.87, 95% CI = 0.48–1.58; P = 0.648), homozygous (OR = 0.94, 95% CI = 0.47–1.89; P = 0.865). Similarly, no significant association was found in PON2 Arg148Gly polymorphism under any of the models: allelic (OR = 1.17, 95% CI = 0.91–1.50; P = 0.218), heterozygous (OR = 1.28, 95% CI = 0.94–1.74; P = 0.117), dominant (OR = 1.25, 95% CI = 0.93–1.67; P = 0.142), recessive (OR = 0.99, 95% CI = 0.52–1.88; P = 0.973), homozygous (OR = 1.08, 95% CI = 0.57–2.07; P = 0.808). Conclusions: The PON2 Ser311Cys and Ala148Gly polymorphisms were not associated with the risk of developing T2DM in the Chinese population.
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影响因子：
3
作者：
Li S;Xiao J;Ji L;Weng J;Jia W;Lu J;Zhou Z;Guo X;Liu J;Shan Z;Zhu D;Chen L;Zhao Z;Tian H;Ji Q;Ge J;Li Q;Lin L;Yang Z;He J;Yang W;China National Diabetes and Metabolic Disorders Study Investigators
通讯作者：
China National Diabetes and Metabolic Disorders Study Investigators
欧洲与亚洲对氧磷酶-1 基因多态性与 2 型糖尿病易感性之间关联的差异
影响因子：
5.3
作者：
Luo JQ;Ren H;Liu MZ;Fang PF;Xiang DX
通讯作者：
Xiang DX
影响因子：
4.8
作者：
Ng, CJ;Wadleigh, DJ;Reddy, ST
通讯作者：
Reddy, ST
影响因子：
5.8
作者：
Hegele, RA;Connelly, PW;Zinman, B
通讯作者：
Zinman, B
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG