European versus Asian differences for the associations between paraoxonase-1 genetic polymorphisms and susceptibility to type 2 diabetes mellitus.
European versus Asian differences for the associations between paraoxonase-1 genetic polymorphisms and susceptibility to type 2 diabetes mellitus.
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欧洲与亚洲对氧磷酶-1 基因多态性与 2 型糖尿病易感性之间关联的差异
DOI：
10.1111/jcmm.13453
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发表时间：
2018-03
影响因子：
5.3
通讯作者：
Xiang DX
中科院分区：
文献类型：
--
作者：
Luo JQ;Ren H;Liu MZ;Fang PF;Xiang DX
许多研究探讨了对氧磷酶-1(PON1)基因多态性(Q192R，rs662和L55M，rs854560)与不同民族人群2型糖尿病(T2 DM)易感性的关系。然而，这种联系的证据仍然没有定论。在这项研究中，我们进行了荟萃分析，以阐明两个PON1变异与T2 DM风险的关系。我们系统地检索了PubMed、Embase、CNKI和万方数据库，检索了2017年6月前发表的研究。通过随机或固定效应模型计算关联的合并优势比(OR)及其相应的95%可信区间(CI)。共有50个符合条件的研究确定了PON1 Q192R(Rs662)和L55M(Rs854560)的多态性，包括34个和16个研究。PON1 Q192R等位基因在南亚和东亚人群中是T2 DM的易感基因(OR>；1，P<；0.05)，但在欧洲人群中代表了T2 DM的保护因素(OR=0.66，95%CI=0.45~0.98)。在PON1 L55M多态中，在杂合(OR=0.77，95%CI=0.61~0.97)和显性(OR=0.80，95%CI=0.65~0.99)两种遗传模式下，欧洲人群对T2 DM的保护作用显著，而亚洲人群在所有遗传模式下均无显著相关性(P>；0.05)。综上所述，通过综合荟萃分析，我们的结果有力地表明，PON1基因多态性在不同种族背景下对T2 DM的风险存在明显的影响。
Many studies have examined the associations between paraoxonase‐1 (PON1) genetic polymorphisms (Q192R, rs662 and L55M, rs854560) and the susceptibility to type 2 diabetes mellitus (T2DM) across different ethnic populations. However, the evidence for the associations remains inconclusive. In this study, we performed a meta‐analysis to clarify the association of the two PON1 variants with T2DM risk. We carried out a systematic search of PubMed, Embase, CNKI and Wanfang databases for studies published before June 2017. The pooled odds ratios (ORs) for the association and their corresponding 95% confidence intervals (CIs) were calculated by a random‐ or fixed‐effect model. A total of 50 eligible studies, including 34 and 16 studies were identified for the PON1 Q192R (rs662) and L55M (rs854560) polymorphism, respectively. As for the PON1 Q192R polymorphism, the 192R allele was a susceptible factor of T2DM in the South or East Asian population (OR > 1, P < 0.05) but represented a protective factor of T2DM in European population (OR = 0.66, 95% CI = 0.45–0.98) under a heterozygous genetic model. With regard to the PON1 L55M polymorphism, significant protective effects of the 55M allele on T2DM under the heterozygous (OR = 0.77, 95% CI = 0.61–0.97) and dominant (OR = 0.80, 95% CI = 0.65–0.99) genetic models were found in the European population, while no significant associations in the Asian populations under all genetic models (P > 0.05). In summary, by a comprehensive meta‐analysis, our results firmly indicated that distinct effects of PON1 genetic polymorphisms existed in the risk of T2DM across different ethnic backgrounds.
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