Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner.
Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner.
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DOI：
10.1111/cmi.12212
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发表时间：
2014-05
影响因子：
3.4
通讯作者：
Langhorne J
中科院分区：
文献类型：
--
作者：
Brugat T;Cunningham D;Sodenkamp J;Coomes S;Wilson M;Spence PJ;Jarra W;Thompson J;Scudamore C;Langhorne J
感染疟疾寄生虫，疟原虫，与强烈的炎症反应和寄生虫细胞粘附（隔离）在几个器官。在这里，我们进行了系统的研究隔离和组织病理学感染C57 B1/6小鼠与疟原虫夏氏AS和确定的免疫反应的影响。 这种寄生虫主要在肝脏和肺中隔离，但不在大脑，肾脏或肠道中。在急性感染期间，多个器官发生组织学变化，但不限于发生隔离的器官。适应性免疫和通过IFNγ受体的信号传导增加了肝脏中的隔离和组织病理学，但在肺中没有，这表明这两个器官中使用的粘附分子和/或寄生虫配体以及发病机制存在差异。在感染过程中，IL 10基因缺失导致的促炎反应的加剧，无论隔离的程度如何，都会加重肺和肾的损伤。因此，免疫应答以器官特异性方式影响隔离和组织病理学。夏氏疟原虫AS为研究宿主反应对隔离作用和特定器官病理的影响提供了一个良好的模型，适用于人类疟疾。
Infection with the malaria parasite, Plasmodium, is associated with a strong inflammatory response and parasite cytoadhesion (sequestration) in several organs. Here, we have carried out a systematic study of sequestration and histopathology during infection of C57Bl/6 mice with Plasmodium chabaudi AS and determined the influence of the immune response. This parasite sequesters predominantly in liver and lung, but not in the brain, kidney or gut. Histopathological changes occur in multiple organs during the acute infection, but are not restricted to the organs where sequestration takes place. Adaptive immunity, and signalling through the IFNγ receptor increased sequestration and histopathology in the liver, but not in the lung, suggesting that there are differences in the adhesion molecules and/or parasite ligands utilized and mechanisms of pathogenesis in these two organs. Exacerbation of pro-inflammatory responses during infection by deletion of the il10 gene resultsin the aggravation of damage to lung and kidney irrespective of the degree of sequestration. The immune response therefore affected both sequestration and histopathology in an organ-specific manner. P. chabaudi AS provides a good model to investigate the influence of the host response on the sequestration and specific organ pathology, which is applicable to human malaria.
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DOI：
10.1086/510756
发表时间：
2007-02-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Anstey NM;Handojo T;Pain MC;Kenangalem E;Tjitra E;Price RN;Maguire GP
通讯作者：
Maguire GP
影响因子：
6.4
作者：
Carvalho, Bruna O.;Lopes, Stefanie C. P.;Costa, Fabio T. M.
通讯作者：
Costa, Fabio T. M.
影响因子：
3
作者：
Cox-Singh J;Hiu J;Lucas SB;Divis PC;Zulkarnaen M;Chandran P;Wong KT;Adem P;Zaki SR;Singh B;Krishna S
通讯作者：
Krishna S
间日疟原虫疟疾临床诊断患者的尸检特征：这种寄生虫的杀伤力有多大？
影响因子：
11.8
作者：
Lacerda, Marcus V. G.;Fragoso, Silvio C. P.;Bassat, Quique
通讯作者：
Bassat, Quique
影响因子：
4.4
作者：
Lawton J;Brugat T;Yan YX;Reid AJ;Böhme U;Otto TD;Pain A;Jackson A;Berriman M;Cunningham D;Preiser P;Langhorne J
通讯作者：
Langhorne J