Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation.
Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation.
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DOI：
10.1086/510756
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发表时间：
2007-02-15
期刊：
影响因子：
--
通讯作者：
Maguire GP
中科院分区：
文献类型：
--
作者：
Anstey NM;Handojo T;Pain MC;Kenangalem E;Tjitra E;Price RN;Maguire GP
间日疟疾肺损伤的机制尚不清楚。据我们所知，对恶性疟原虫和间日疟原虫的炎症反应以前还没有在器官水平上进行过比较。对印度尼西亚成人无并发症间日疟（n = 50）和恶性疟（n = 50）患者的呼吸道症状和生理方面进行了纵向测量。109名对照受试者的正常值。将气体传递分为肺泡-毛细血管膜（DM）和肺毛细血管（VC）两部分，表征气体传递受损的部位和时间。间日疟和恶性疟的平均基线VC体积显著降低，并随着每种疟疾的治疗而改善。两种动物的基线DM功能均未受损。间日疟治疗后DM功能的进行性恶化有统计学意义，而非恶性疟治疗后无统计学意义。间日疟治疗后血氧饱和度恶化，恶性疟治疗后血氧饱和度改善。VC体积的基线降低而DM功能的基线降低提示被寄生红细胞侵入了VC体积，提示间日疟原虫感染的红细胞可能在肺微血管内被隔离。间日疟治疗后进行性肺泡毛细血管功能障碍与间日疟相对于恶性疟原虫对特定寄生虫负荷的更大炎症反应相一致。
The mechanisms underlying lung injury in vivax malaria are not well understood. Inflammatory responses to Plasmodium falciparum and P. vivax, to our knowledge, have not previously been compared at an organ level. Respiratory symptoms and physiological aspects were measured longitudinally in Indonesian adults with uncomplicated vivax (n = 50) and falciparum (n = 50) malaria. Normal values were derived from 109 control subjects. Gas transfer was partitioned into its alveolar-capillary membrane (DM) and pulmonary capillary vascular (VC) components, to characterize the site and timing of impaired gas transfer. Mean baseline VC volume was significantly reduced in vivax and falciparum malaria, improving with treatment in each species. Baseline DM function was not impaired in either species. The progressive deterioration in DM function after treatment was statistically significant in vivax malaria but not in uncomplicated falciparum malaria. Oxygen saturation deteriorated after treatment in vivax but improved in falciparum malaria. The baseline reduction in VC volume but not in DM function suggests encroachment on VC volume by parasitized erythrocytes and suggests that P. vivax–infected erythrocytes may sequester within the pulmonary microvasculature. Progressive alveolar-capillary dysfunction after treatment of vivax malaria is consistent with a greater inflammatory response to a given parasite burden in P. vivax relative to that in P. falciparum.
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影响因子：
11.8
作者：
Kochar DK;Saxena V;Singh N;Kochar SK;Kumar SV;Das A
通讯作者：
Das A
DOI：
10.1080/00034983.1985.11811899
发表时间：
1985-01-01
影响因子：
--
作者：
JAMES, MFM
通讯作者：
JAMES, MFM
影响因子：
120.7
作者：
Kotwal, RS;Wenzel, RB;Petruccelli, BP
通讯作者：
Petruccelli, BP
影响因子：
11.8
作者：
Curlin, ME;Barat, LM;Granger, DL
通讯作者：
Granger, DL
DOI：
10.1073/pnas.89.8.3200
发表时间：
1992-04-15
影响因子：
11.1
作者：
KARUNAWEERA, ND;GRAU, GE;MENDIS, KN
通讯作者：
MENDIS, KN