TGF-β Signaling from Receptors to Smads.
TGF-β Signaling from Receptors to Smads.
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从受体到 Smads 的 TGF-β 信号传导
DOI：
10.1101/cshperspect.a022061
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发表时间：
2016-09-01
影响因子：
7.2
通讯作者：
Chen YG
中科院分区：
文献类型：
--
作者：
Hata A;Chen YG
转化生长因子β（TGF-β）和相关的生长因子是分泌的多效因素，通过调节细胞增殖，分化，死亡和迁移，在胚胎发生和成人组织稳态中起关键作用。 I型和II型接收器，激活信号传感器的Smad家族的成员。上下文依赖性。揭示了TGF-βS编码上下文依赖性信号的框架，该信号包括信号通路的主元素的各种正和负修饰符，接收器，接收器，和SMAD蛋白质。小型非编码RNA。
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating cell proliferation, differentiation, death, and migration. The TGF-β family members signal via heteromeric complexes of type I and type II receptors, which activate members of the Smad family of signal transducers. The main attribute of the TGF-β signaling pathway is context-dependence. Depending on the concentration and type of ligand, target tissue, and developmental stage, TGF-β family members transmit distinct signals. Deregulation of TGF-β signaling contributes to developmental defects and human diseases. More than a decade of studies have revealed the framework by which TGF-βs encode a context-dependent signal, which includes various positive and negative modifiers of the principal elements of the signaling pathway, the receptors, and the Smad proteins. In this review, we first introduce some basic components of the TGF-β signaling pathways and their actions, and then discuss posttranslational modifications and modulatory partners that modify the outcome of the signaling and contribute to its context-dependence, including small noncoding RNAs.
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DOI：
10.1083/jcb.200612046
发表时间：
2007-07-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Atfi A;Dumont E;Colland F;Bonnier D;L'helgoualc'h A;Prunier C;Ferrand N;Clément B;Wewer UM;Théret N
通讯作者：
Théret N
SMAD介导的microRNA生物合成调节。
影响因子：
3.5
作者：
Blahna MT;Hata A
通讯作者：
Hata A
影响因子：
10.5
作者：
Aragon, Eric;Goerner, Nina;Macias, Maria J.
通讯作者：
Macias, Maria J.
影响因子：
10.8
作者：
Blumensatt, Marcel;Greulich, Sabrina;Ouwens, D. Margriet
通讯作者：
Ouwens, D. Margriet
影响因子：
11.4
作者：
Chen, YG;Liu, F;Massague, J
通讯作者：
Massague, J