Genetic influences on the cognitive biases associated with anxiety and depression symptoms in adolescents.
Genetic influences on the cognitive biases associated with anxiety and depression symptoms in adolescents.
复制标题
遗传对青少年焦虑和抑郁症状相关认知偏差的影响。
DOI：
10.1016/j.jad.2009.10.030
复制
发表时间：
2010
影响因子：
6.6
通讯作者：
Zavos HM
中科院分区：
文献类型：
--
作者：
Zavos HM
背景影响焦虑和抑郁的基因之间存在大量重叠。焦虑和抑郁都与认知偏差有关，例如焦虑敏感性和归因方式。然而，人们对这些变量之间的关系以及这些变量是否也具有遗传相关性知之甚少。方法对 1300 多对青少年双胞胎和兄弟姐妹在两个时间点的焦虑敏感性、焦虑症状、归因风格和抑郁症状进行自我报告。检查了遗传和环境对测量的影响程度。结果发现两个测量时间的焦虑敏感性和焦虑评级之间（r=.70，.72）以及焦虑和抑郁之间（两个时间点的r=.62）之间存在最强的关联。认知偏差之间的相关性在时间 1 时较小 (r=−.12)，在时间 2 时稍大一些 (r=−.31)。所有测量结果均显示出中等程度的遗传影响。一般来说，遗传相关性反映了表型相关性。因此，最高的遗传相关性是焦虑敏感性和焦虑评级之间（0.86，0.87）以及焦虑和抑郁评级之间（0.77，0.71）。有趣的是，抑郁评级也显示出与焦虑敏感性的高度遗传相关性（0.70，0.76）。认知偏差测量之间的遗传相关性中等（−.31，−.46）。 局限性样本主要由双胞胎组成，双胞胎设计存在局限性。结论与抑郁和焦虑相关的认知偏差并不像焦虑和抑郁评级本身那样具有遗传相关性。对与焦虑和抑郁相关的认知过程的进一步研究将有助于理解偏见和症状之间的关系。
BACKGROUNDThere is a substantial overlap between genes affecting anxiety and depression. Both anxiety and depression are associated with cognitive biases such as anxiety sensitivity and attributional style. Little, however, is known about the relationship between these variables and whether these too are genetically correlated.METHODSSelf-reports of anxiety sensitivity, anxiety symptoms, attributional style and depression symptoms were obtained for over 1300 adolescent twin and sibling pairs at two time points. The magnitude of genetic and environmental influences on the measures was examined.RESULTSStrongest associations were found between anxiety sensitivity and anxiety ratings at both measurement times (r=.70, .72) and between anxiety and depression (r=.62 at both time points). Correlations between the cognitive biases were modest at time 1 (r=−.12) and slightly larger at time 2 (r=−.31). All measures showed moderate genetic influence. Generally genetic correlations reflected phenotypic correlations. Thus the highest genetic correlations were between anxiety sensitivity and anxiety ratings (0.86, 0.87) and between anxiety and depression ratings (.77, .71). Interestingly, depression ratings also showed a high genetic correlation with anxiety sensitivity (.70, .76). Genetic correlations between the cognitive bias measures were moderate (−.31, −.46).LIMITATIONSThe sample consists primarily of twins, there are limitations associated with the twin design.CONCLUSIONSCognitive biases associated with depression and anxiety are not as genetically correlated as anxiety and depression ratings themselves. Further research into the cognitive processes related to anxiety and depression will facilitate understanding of the relationship between bias and symptoms.
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影响因子：
--
作者：
Jaffee, SR;Moffitt, TE;Martin, J
通讯作者：
Martin, J
患有焦虑症的成年人的青少年心理健康史。
DOI：
10.1176/ajp.2007.164.2.301
发表时间：
2007
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Gregory,AliceM;Caspi,Avshalom;Moffitt,TerrieE;Koenen,Karestan;Eley,ThaliaC;Poulton,Richie
通讯作者：
Poulton,Richie
影响因子：
4.1
作者：
Muris, P;Schmidt, H;Schouten, E
通讯作者：
Schouten, E
影响因子：
4.1
作者：
Weems, CF;HammondLaurence, K;Ferguson, C
通讯作者：
Ferguson, C
影响因子：
3.6
作者：
Thompson, M;Kaslow, NJ;Nolen-Hoeksema, S
通讯作者：
Nolen-Hoeksema, S