Dopamine-Mediated Circadian and Light/Dark-Adaptive Modulation of Chemical and Electrical Synapses in the Outer Retina.
Dopamine-Mediated Circadian and Light/Dark-Adaptive Modulation of Chemical and Electrical Synapses in the Outer Retina.
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DOI：
10.3389/fncel.2021.647541
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发表时间：
2021
影响因子：
5.3
通讯作者：
Mangel SC
中科院分区：
文献类型：
--
作者：
Goel M;Mangel SC
像大多数其他大脑区域一样，脊椎动物的视网膜在神经信号方面经历了相对缓慢的变化，以响应生理条件的逐渐变化(例如，从活动到休息的变化)，或对环境条件的逐渐变化(例如，从白天到夜晚的变化)。正如在大脑的其他地方发生的那样，在视网膜中调节缓慢适应的调节过程是由外部信号(例如，环境光线水平的变化)和/或由内在信号驱动的，例如视网膜中的昼夜节律(24-h)时钟的信号。这篇综述文章描述和讨论了外在和内在的调制过程，使视网膜中的神经回路能够在环境光水平变化约100亿倍时，在白天和夜晚优化其视觉性能。在视网膜的第一层突触中，视锥感光细胞与视杆和信号视锥-双极细胞和水平细胞形成缝隙连接。这一突触层不同的外在和内在的调制过程是由神经调节剂多巴胺的远程反馈所介导的。多巴胺是由多巴胺能细胞释放的，多巴胺能细胞的胞体位于视网膜的第二突触层。多巴胺在白天和夜间调节化学和电突触的不同作用。与夜间相比，视网膜生物钟在白天增加了多巴胺的释放，激活了视锥细胞上高亲和力的多巴胺D4受体。这种时钟效应控制着视杆和视锥之间的电突触，因此视杆-视锥之间的电耦合在白天最小，在晚上很强。夜间棒-锥耦合的增加提高了极暗多光子光响应的信噪比和可靠性，从而增强了在无月之夜对大型昏暗物体的探测。相反，与保持黑暗相比，白天保持(30分钟)的明亮光照释放了足够的多巴胺来激活锥体-双极细胞树突上的低亲和力多巴胺D1受体。这种非昼夜的明/暗适应过程调节了GABAA受体在锥体上双极细胞树突上的功能，从而使细胞周围的感受野(RF)在维持明亮光照时较强，但在维持黑暗时最小。在保持明亮照明后的第二天，环绕强度的增加增强了对边缘和精细空间细节的检测。
The vertebrate retina, like most other brain regions, undergoes relatively slow alterations in neural signaling in response to gradual changes in physiological conditions (e.g., activity changes to rest), or in response to gradual changes in environmental conditions (e.g., day changes into night). As occurs elsewhere in the brain, the modulatory processes that mediate slow adaptation in the retina are driven by extrinsic signals (e.g., changes in ambient light level) and/or by intrinsic signals such as those of the circadian (24-h) clock in the retina. This review article describes and discusses the extrinsic and intrinsic modulatory processes that enable neural circuits in the retina to optimize their visual performance throughout day and night as the ambient light level changes by ~10 billion-fold. In the first synaptic layer of the retina, cone photoreceptor cells form gap junctions with rods and signal cone-bipolar and horizontal cells (HCs). Distinct extrinsic and intrinsic modulatory processes in this synaptic layer are mediated by long-range feedback of the neuromodulator dopamine. Dopamine is released by dopaminergic cells, interneurons whose cell bodies are located in the second synaptic layer of the retina. Distinct actions of dopamine modulate chemical and electrical synapses in day and night. The retinal circadian clock increases dopamine release in the day compared to night, activating high-affinity dopamine D4 receptors on cones. This clock effect controls electrical synapses between rods and cones so that rod-cone electrical coupling is minimal in the day and robust at night. The increase in rod-cone coupling at night improves the signal-to-noise ratio and the reliability of very dim multi-photon light responses, thereby enhancing detection of large dim objects on moonless nights.Conversely, maintained (30 min) bright illumination in the day compared to maintained darkness releases sufficient dopamine to activate low-affinity dopamine D1 receptors on cone-bipolar cell dendrites. This non-circadian light/dark adaptive process regulates the function of GABAA receptors on ON-cone-bipolar cell dendrites so that the receptive field (RF) surround of the cells is strong following maintained bright illumination but minimal following maintained darkness. The increase in surround strength in the day following maintained bright illumination enhances the detection of edges and fine spatial details.
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外丛状层中的双极细胞突触上的异位视网膜：与多巴胺能小链氨酸细胞和黑色素蛋白神经节细胞的接触。
DOI：
10.1002/cne.22158
发表时间：
2009-11-10
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Dumitrescu ON;Pucci FG;Wong KY;Berson DM
通讯作者：
Berson DM
DOI：
10.1016/j.cub.2017.07.063
发表时间：
2017-09-11
期刊：
Current biology : CB
影响因子：
--
作者：
Chaffiol A;Ishii M;Cao Y;Mangel SC
通讯作者：
Mangel SC
影响因子：
1.9
作者：
Fahey, PK;Burkhardt, DA
通讯作者：
Burkhardt, DA
DOI：
10.1073/pnas.89.19.9220
发表时间：
1992-10-01
影响因子：
11.1
作者：
HARSANYI, K;MANGEL, SC
通讯作者：
MANGEL, SC
影响因子：
1.8
作者：
Dacey, D;Packer, OS;Lee, B
通讯作者：
Lee, B