The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong.
The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong.
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DOI：
10.1086/656740
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发表时间：
2010-11-15
期刊：
影响因子：
--
通讯作者：
Malik Peiris JS
中科院分区：
文献类型：
--
作者：
Wu JT;Ma ES;Lee CK;Chu DK;Ho PL;Shen AL;Ho A;Hung IF;Riley S;Ho LM;Lin CK;Tsang T;Lo SV;Lau YL;Leung GM;Cowling BJ;Malik Peiris JS
2009年甲型H1N1流感病毒抗体水平的连续横断面数据可用于估计社区的感染率和对未来感染的免疫力。在2009年4月至12月期间，我们从献血者（16-59岁）、医院门诊患者（5- 59岁）和社区儿科队列研究受试者（5- 14岁）中获得了12，217份血清标本。我们通过比较第一波大流行前后病毒微量中和抗体滴度≥1：40的标本比例来估计感染发作率。使用跨越第一波的324个个体的配对血清验证估计值。将这些估计值与流行病学监测数据相结合，我们计算了导致住院、重症监护和死亡的感染比例。第一波前后抗体滴度≥1：40的5-59岁儿童分别为3.3%和14%。总体发病率为10.7%，年龄分层如下：5-14岁43.4%，15-19岁15.8%，20-29岁11.8%，30-59岁4-4.6%。5-59岁人群的病例住院率为0.47%-0.87%。ICU病例和病死率从5-14岁的7.9/100，000和0.4/100，000感染增加到50-59岁的75/100，000和26.5/100，000感染。在第一波疫情中，香港几乎一半的学童受到感染。与5-14岁的学龄儿童相比，50-59岁的老年人如果感染，入住ICU和死亡的风险分别高出9.5和66倍。
Serial cross-sectional data on antibody levels to 2009 pandemic influenza A (H1N1) virus from a population can be used to estimate the infection attack rates and immunity against future infection in the community. Between April and December 2009, we obtained 12,217 serum specimens from blood donors (16–59 yo), 2,520 from hospital outpatients (5–59yo), and 917 from subjects of a community pediatric cohort study (5–14yo). We estimated infection attack rates by comparing the proportions of specimens with antibody titers ≥1:40 by viral microneutralization before and after the first wave of the pandemic. Estimates were validated using paired sera from 324 individuals that spanned the first wave. Combining these estimates with epidemiologic surveillance data, we calculated the proportion of infections that led to hospitalization, intensive care admission, and death. We found that 3.3% and 14% of 5–59 yo had antibody titers ≥1:40 before and after the first wave. The overall attack rate was 10.7% with the following age-stratification: 43.4% in 5–14 yo, 15.8% in 15–19 yo, 11.8% in 20–29 yo, and 4–4.6% in 30–59 yo. Case-hospitalization rates were 0.47%–0.87% among 5–59 yo. Case-ICU and case-fatality rates increased from 7.9 and 0.4 per 100,000 infections in 5–14 yo to 75 and 26.5 per 100,000 infections in 50–59 yo. Almost half of all school-children in Hong Kong were infected during the first wave. Compared to school-children aged 5–14, older adults aged 50–59 had 9.5 and 66 times higher risk of ICU admission and death if infected.
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影响因子：
168.9
作者：
Echevarria-Zuno, Santiago;Manuel Mejia-Arangure, Juan;Hugo Borja-Aburto, Victor
通讯作者：
Hugo Borja-Aburto, Victor
影响因子：
11.8
作者：
Wu JT;Cowling BJ;Lau EH;Ip DK;Ho LM;Tsang T;Chuang SK;Leung PY;Lo SV;Liu SH;Riley S
通讯作者：
Riley S
DOI：
10.1136/bmj.b5213
发表时间：
2009-12-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Donaldson LJ;Rutter PD;Ellis BM;Greaves FE;Mytton OT;Pebody RG;Yardley IE
通讯作者：
Yardley IE
影响因子：
11.8
作者：
Wong, CM;Chan, KP;Peiris, JSM
通讯作者：
Peiris, JSM
影响因子：
5
作者：
Basta NE;Chao DL;Halloran ME;Matrajt L;Longini IM Jr
通讯作者：
Longini IM Jr