The puzzling role of TRPC3 channels in motor coordination.
The puzzling role of TRPC3 channels in motor coordination.
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DOI：
10.1007/s00424-009-0740-5
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发表时间：
2010-02
影响因子：
4.5
通讯作者：
Trebak, Mohamed
中科院分区：
文献类型：
--
作者：
Trebak, Mohamed
瞬时受体电位规范3 （TRPC3）蛋白是磷脂酶C （PLC）偶联受体下游激活的非选择性阳离子通道。TRPC3通道在中枢神经系统（CNS）的功能中起着重要的作用。它们被描述为脑源性神经营养因子（BDNF）介导的小脑颗粒神经元存活和生长锥引导的重要贡献者。TRPC3也被认为是小脑浦肯野神经元中代谢性谷氨酸受体1 （mGluR1）依赖性突触传递所必需的突触后阳离子通道。最近的一份报告描述了TRPC3敲除小鼠的运动协调缺陷，而随后的一项研究报告了所谓的月球漫步小鼠的类似表型，其中包含TRPC3功能突变的增加。TRPC3通道激活的相反方面如何导致相同的表型？在这里，我们讨论了TRPC3敲除小鼠和月球漫步小鼠的显著特征，并试图调和这两种动物模型中明显相互矛盾的发现。
Transient receptor potential canonical 3 (TRPC3) proteins are nonselective cation channels activated downstream of Phospholipase C (PLC)-coupled receptors. TRPC3 channels have emerged as major players in the function of the central nervous system (CNS). They have been described as important contributors to brain-derived neurotrophic factor (BDNF)-mediated survival and growth-cone guidance of cerebellar granule neurons. TRPC3 were also identified as postsynaptic cation channels essential for metabotropic glutamate receptor1 (mGluR1)-dependent synaptic transmission in cerebellar Purkinje neurons. A recent report described motor coordination defects in TRPC3 knockout mice while a subsequent study reported a similar phenotype in so-called moonwalker mice, harboring a TRPC3 gain of function mutation. How can opposing aspects of TRPC3 channel activation lead to the same phenotype? Here we discuss the salient features of TRPC3 knockout mice and moonwalker mice and attempt to reconcile the apparently conflicting findings from these two animal models.
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影响因子：
4
作者：
Huang, W.-C.;Young, J. S.;Glitsch, M. D.
通讯作者：
Glitsch, M. D.
DOI：
10.1073/pnas.0810599106
发表时间：
2009-04-21
影响因子：
11.1
作者：
Becker, Esther B. E.;Olivera, Peter L.;Davies, Kay E.
通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
Marmolino, Danielle
影响因子：
5.3
作者：
Amaral, Michelle D.;Pozzo-Miller, Lucas
通讯作者：
Pozzo-Miller, Lucas
影响因子：
5.3
作者：
Dietrich, A;Schnitzler, MMY;Birnbaumer, L
通讯作者：
Birnbaumer, L