Myocyte [Na(+)](i) Dysregulation in Heart Failure and Diabetic Cardiomyopathy.
Myocyte [Na(+)](i) Dysregulation in Heart Failure and Diabetic Cardiomyopathy.
复制标题
DOI：
10.3389/fphys.2018.01303
复制
发表时间：
2018
影响因子：
4
通讯作者：
Despa S
中科院分区：
文献类型：
--
作者：
Despa S
By controlling the function of various sarcolemmal and mitochondrial ion transporters, intracellular Na+ concentration ([Na+]i) regulates Ca2+ cycling, electrical activity, the matching of energy supply and demand, and oxidative stress in cardiac myocytes. Thus, maintenance of myocyte Na+ homeostasis is vital for preserving the electrical and contractile activity of the heart. [Na+]i is set by the balance between the passive Na+ entry through numerous pathways and the pumping of Na+ out of the cell by the Na+/K+-ATPase. This equilibrium is perturbed in heart failure, resulting in higher [Na+]i. More recent studies have revealed that [Na+]i is also increased in myocytes from diabetic hearts. Elevated [Na+]i causes oxidative stress and augments the sarcoplasmic reticulum Ca2+ leak, thus amplifying the risk for arrhythmias and promoting heart dysfunction. This mini-review compares and contrasts the alterations in Na+ extrusion and/or Na+ uptake that underlie the [Na+]i increase in heart failure and diabetes, with a particular emphasis on the emerging role of Na+ - glucose cotransporters in the diabetic heart.
登录
查看更多内容
影响因子：
37.8
作者：
Despa, S;Islam, MA;Bers, DM
通讯作者：
Bers, DM
影响因子：
8.2
作者：
Anzawa, R;Bernard, M;Feuvray, D
通讯作者：
Feuvray, D
影响因子：
10.8
作者：
Boguslavskyi, Andrii;Pavlovic, Davor;Shattock, Michael J.
通讯作者：
Shattock, Michael J.
影响因子：
8.2
作者：
Boudina, Sihem;Abel, Evan Dale
通讯作者：
Abel, Evan Dale
影响因子：
3.2
作者：
Babsky, A;Doliba, N;Osbakken, M
通讯作者：
Osbakken, M