Nerve Fiber Growth and Its Regulation by Extrinsic Factors
Nerve Fiber Growth and Its Regulation by Extrinsic Factors
复制标题
神经纤维的生长及其受外在因素的调节
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
Paul C. Letourneau
中科院分区：
文献类型：
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作者：
Paul C. Letourneau
胚胎发生的一个显著特征是神经元轴突向神经系统和其他器官中的靶细胞的精细延伸。这种神经纤维的生长通常沿着特定的路径产生特定的神经支配模式。这种精确的组织需要高度的调节，胚胎和再生组织的操作表明，轴突通常由它们生长的环境中的线索指导。1 -4本文讨论了轴突如何生长，并检查了两个因素，细胞基质粘附和趋化反应，作为轴突生长的主要环境调节因子。讨论仅限于组织培养研究，因为生长的神经纤维更容易观察，操作，并在体外比在体内进行高分辨率的形态学和细胞化学研究。此外，可以在体外测试和彻底评估神经纤维生长的潜在外源性调节剂。
A remarkable feature of embryogenesis is the elaborate extension of axons by neurons to target cells in the nervous system and in other organs. This growth of nerve fibers often traces characteristic pathways to produce specific patterns of innervation. Such precise organization requires a high degree of regulation, and manipulations of embryonal and regenerating tissues have shown that axons are usually directed by cues within the environments through which they grow.1–4 This essay discusses how axons grow and examines two factors, cell-substratum adhesion and chemotactic responses, as principal environmental regulators of axonal growth. Discussion is restricted to tissue culture studies, because growing nerve fibers are more easily observed, manipulated, and subjected to high-resolution morphological and cytochemical studies in vitro than in vivo. In addition, potential extrinsic modulators of nerve fiber growth can be tested and thoroughly evaluated in vitro.
影响因子：
2.7
作者：
Fraser,SE
通讯作者：
Fraser,SE
神经节起源的聚鸟氨酸附着材料的神经炎引导。
影响因子：
2.7
作者：
Adler,R;Varon,SU
通讯作者：
Varon,SU