Optimal performance in a countermanding saccade task.

Optimal performance in a countermanding saccade task.
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DOI:
10.1016/j.brainres.2009.12.018
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发表时间:
2010-03-08
期刊:
影响因子:
2.9
通讯作者:
Cohen, Jonathan D.
Cohen, Jonathan D.
中科院分区:
医学3区
文献类型:
--
作者:
Wong-Lin, KongFatt;Eckhoff, Philip;Holmes, Philip;Cohen, Jonathan D.

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撤销命令是认知控制的一种基本形式。在扫视-撤销任务中,受试者被指示,如果停止信号在目标之后不久出现,则他们要保持注视而不是对目标进行扫视。近年来,在行为非人类灵长类动物的额叶眼区和上级丘的记录中发现了运动和固定神经元中这种撤销行为的相关性。在这项工作中,我们扩展了以前的神经网络模型的countermanding占高前目标活动的固定神经元。我们认为,这种活动反映了负责优化性能的控制机制的功能。我们证明,使用计算机模拟和数学分析,前目标固定神经元活动支持countermanding行为,最大限度地提高奖励率的函数的停止信号延迟,停止信号试验的分数,试验间隔,超时的持续时间,和相对奖励值。我们提出实验来测试这些预测的最佳行为。
Countermanding an action is a fundamental form of cognitive control. In a saccade-countermanding task, subjects are instructed that, if a stop signal appears shortly after a target, they are to maintain fixation rather than to make a saccade to the target. In recent years, recordings in the frontal eye fields and superior colliculus of behaving non-human primates have found correlates of such countermanding behavior in movement and fixation neurons. In this work, we extend a previous neural network model of countermanding to account for the high pre-target activity of fixation neurons. We propose that this activity reflects the functioning of control mechanisms responsible for optimizing performance. We demonstrate, using computer simulations and mathematical analysis, that pre-target fixation neuronal activity supports countermanding behavior that maximizes reward rate as a function of the stop signal delay, fraction of stop signal trials, intertrial interval, duration of timeout, and relative reward value. We propose experiments to test these predictions regarding optimal behavior.
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