Resting heart rate and risk of left and right heart failure in 0.5 million Chinese adults.
Resting heart rate and risk of left and right heart failure in 0.5 million Chinese adults.
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作者：
比较中国成年人静息心率（RHR）与心力衰竭（HF）和肺心病（PHD）的关系。2004 - 2008年，中国嘉道理生物样本库从中国10个不同地理区域（5个城市，5个农村）招募了超过50万名成年人。经过11年的随访，在491785名基线时没有心脏病史或使用β受体阻滞剂的参与者中记录了6082例HF事件和5572例PHD病例。调整混杂因素后，考克斯回归得出了与通常RHR相关的每种疾病的HR。平均（SD）基线RHR为79（12）（男性为78（12）;女性为80（11））bpm，并且随着年龄的增加而降低（每10岁约1 bpm）。肾性RHR与HF呈J型相关，与PHD呈对数线性相关。对于HF，RHR> 75 bpm时，正常RHR每高10 bpm，校正HR为1.25（95% CI 1.17至1.34）。对于PHD，在正常RHR的整个范围内，RHR每高10 bpm与HR 1.74（1.67 - 1.81）相关。对于RHR> 75 bpm的HF而不是PHD，通过进一步调整糖尿病和高血压，每10 bpm高RHR的HR大约减半。在整个研究范围内，RHR与PHD呈强正相关，但仅在RHR> 75 bpm时与HF相关，且与HF相关的强度仅为PHD的三分之一。
To compare the shape and strength of the associations of resting heart rate (RHR) with incident heart failure (HF) and pulmonary heart disease (PHD) in Chinese adults. The prospective China Kadoorie Biobank recruited >0.5 million adults from 10 geographically diverse regions (5 urban, 5 rural) of China during 2004–2008. After an 11-year follow-up, 6082 incident cases of HF and 5572 cases of PHD, were recorded among 491 785 participants with no prior history of heart disease or use of beta-blockers at baseline. Cox regression yielded HRs for each disease associated with usual RHR after adjustment for confounding factors. The mean (SD) baseline RHR was 79 (12) (men 78 (12); women 80 (11)) bpm, and these decreased with increasing age (by about 1 bpm per 10 years). Usual RHR showed J-shaped associations with HF and log-linear associations PHD. For HF, each 10 bpm higher usual RHR was associated with an adjusted HR of 1.25 (95% CI 1.17 to 1.34) for RHR>75 bpm. For PHD, each 10 bpm higher RHR was associated with HR of 1.74 (1.67–1.81) across the full range of usual RHR. For HF at RHR>75 bpm but not PHD, the HRs per 10 bpm higher RHR were approximately halved by further adjustment for diabetes and hypertension. RHR was strongly positively associated with PHD throughout the range studied, but was only associated with HF at RHR>75 bpm, and the strength of the associations with HF were only one-third of those with PHD.
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影响因子：
18.2
作者：
Nanchen, David;Stott, David J.;de Craen, Anton J. M.
通讯作者：
de Craen, Anton J. M.
影响因子：
24
作者：
Opdahl, Anders;Venkatesh, Bharath Ambale;Fernandes, Veronica R. S.;Wu, Colin O.;Nasir, Khurram;Choi, Eui-Young;Almeida, Andre L. C.;Rosen, Boaz;Carvalho, Benilton;Edvardsen, Thor;Bluemke, David A.;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.
影响因子：
2.6
作者：
Forfia PR;Vaidya A;Wiegers SE
通讯作者：
Wiegers SE
影响因子：
37.8
作者：
Benjamin EJ;Blaha MJ;Chiuve SE;Cushman M;Das SR;Deo R;de Ferranti SD;Floyd J;Fornage M;Gillespie C;Isasi CR;Jiménez MC;Jordan LC;Judd SE;Lackland D;Lichtman JH;Lisabeth L;Liu S;Longenecker CT;Mackey RH;Matsushita K;Mozaffarian D;Mussolino ME;Nasir K;Neumar RW;Palaniappan L;Pandey DK;Thiagarajan RR;Reeves MJ;Ritchey M;Rodriguez CJ;Roth GA;Rosamond WD;Sasson C;Towfighi A;Tsao CW;Turner MB;Virani SS;Voeks JH;Willey JZ;Wilkins JT;Wu JH;Alger HM;Wong SS;Muntner P;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
DOI：
10.1161/circheartfailure.108.768457
发表时间：
2008-07
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Butler J;Kalogeropoulos A;Georgiopoulou V;Belue R;Rodondi N;Garcia M;Bauer DC;Satterfield S;Smith AL;Vaccarino V;Newman AB;Harris TB;Wilson PW;Kritchevsky SB;Health ABC Study
通讯作者：
Health ABC Study