Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
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DOI：
10.1016/j.jacc.2013.11.027
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发表时间：
2014-04-01
影响因子：
24
通讯作者：
Lima, Joao A. C.
中科院分区：
文献类型：
--
作者：
Opdahl, Anders;Venkatesh, Bharath Ambale;Fernandes, Veronica R. S.;Wu, Colin O.;Nasir, Khurram;Choi, Eui-Young;Almeida, Andre L. C.;Rosen, Boaz;Carvalho, Benilton;Edvardsen, Thor;Bluemke, David A.;Lima, Joao A. C.
关键词：
探讨基线静息心率与心力衰竭（HF）发生率及整体和局部左室（LV）功能不全的关系。在无症状的多民族人群中，静息心率与心衰和左室功能的关系尚未得到很好的描述。动脉粥样硬化多种族研究的参与者在纳入时测量静息心率。在随访期间（中位7年），接受心脏MRI （n=5000）的患者记录了HF事件（n=176）。射血分数（ΔEF）和峰值周向应变（Δεcc）的变化被测量为1056名参与者在基线和5年后成像的整体和局部左室功能障碍的标志物。经人口统计学、传统心血管危险因素、钙评分、左室舒张末期容积和质量以及静息心率调整至心力衰竭时间（Cox模型）以及Δεcc和ΔEF（多元线性回归模型）。Cox分析表明，静息心率每增加1 bpm，发生HF的校正相对风险增加4%(危险比：1.04 (1.02,1.06)；P < 0.001)。调整后的多元回归模型表明，静息心率与εcc恶化和EF下降呈正相关，即使在排除所有冠心病事件的分析中也是如此。在MESA无症状参与者中，静息心率升高与HF发生风险增加相关。心率升高与地区性和全局性左室功能障碍的发展有关，与亚临床动脉粥样硬化和冠心病无关。
To investigate the relationship between baseline resting heart rate and incidence of heart failure (HF) and global and regional left ventricular (LV) dysfunction. The association of resting heart rate to HF and LV function is not well described in an asymptomatic multi-ethnic population. Participants in the Multi-Ethnic Study of Atherosclerosis had resting heart rate measured at inclusion. Incident HF was registered (n=176) during follow-up (median 7 years) in those who underwent cardiac MRI (n=5000). Changes in ejection fraction (ΔEF) and peak circumferential strain (Δεcc) were measured as markers of developing global and regional LV dysfunction in 1056 participants imaged at baseline and 5 years later. Time to HF (Cox model) and Δεcc and ΔEF (multiple linear regression models) were adjusted for demographics, traditional cardiovascular risk factors, calcium score, LV end-diastolic volume and mass in addition to resting heart rate. Cox analysis demonstrated that for 1 bpm increase in resting heart rate there was a 4% greater adjusted relative risk for incident HF (Hazard Ratio: 1.04 (1.02, 1.06 (95% CI); P<0.001). Adjusted multiple regression models demonstrated that resting heart rate was positively associated with deteriorating εcc and decrease in EF, even in analyses when all coronary heart disease events were excluded from the model. Elevated resting heart rate is associated with increased risk for incident HF in asymptomatic participants in MESA. Higher heart rate is related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease.
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影响因子：
24
作者：
Fox, Kim;Borer, Jeffrey S.;Tendera, Michal
通讯作者：
Tendera, Michal
影响因子：
4.8
作者：
KANNEL, WB;KANNEL, C;CUPPLES, LA
通讯作者：
CUPPLES, LA
影响因子：
20.1
作者：
JULIUS, S;RANDALL, OS;BENNETT, J
通讯作者：
BENNETT, J
影响因子：
37.8
作者：
Garot, J;Bluemke, DA;Lima, JAC
通讯作者：
Lima, JAC
影响因子：
39.3
作者：
Kolloch, Rainer;Legler, Udo F.;Pepine, Carl J.
通讯作者：
Pepine, Carl J.