Prognostic value of stromal cell-derived factor 1 expression in patients with gastric cancer after surgical resection.
Prognostic value of stromal cell-derived factor 1 expression in patients with gastric cancer after surgical resection.
复制标题
胃癌手术切除后基质细胞衍生因子1表达的预后价值
DOI：
10.1111/cas.12531
复制
发表时间：
2014-11
期刊：
影响因子：
5.7
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Wang X;Zhang H;He H;Shen Z;Tang Z;Xu J;Sun Y
趋化因子基质细胞衍生因子1（SDF-1）表达异常已被证明参与各种恶性肿瘤的发生和进展。本研究旨在探讨SDF-1表达在胃癌患者中的临床和预后价值，并改善危险分层。回顾性分析220例胃癌患者的瘤周和瘤内SDF-1水平，并评估其与临床病理特征和临床结局的关系。建立了预测列线图，以改进胃癌患者总生存率的风险分层。与癌旁组织相比，根据胃癌标本的TNM分期进展，肿瘤组织中的SDF-1表达水平降低。瘤周SDF-1表达与肿瘤浸润深度和淋巴结转移呈正相关，而瘤内SDF-1表达与肿瘤大小、分化程度、浸润深度、淋巴结转移和临床TNM分期呈负相关。此外，肿瘤周围SDF-1低表达和肿瘤内SDF-1高表达均表明良好的总生存率，并且来自肿瘤周围/肿瘤内SDF-1表达特征的SDF-1风险可以对胃癌患者的预后进行分层。后向消除后，SDF-1风险被确定为生存的独立预后因素。最后，用确定的独立指标生成预测列线图，以评估术后3年和5年的患者生存率。结论，SDF-1风险，一个确定的独立预后因素，可以发展成一个诺模图与肿瘤浸润深度，淋巴结受累，和远处转移，以改善胃癌患者手术切除后生存的预测准确性。
Aberrant chemokine stromal cell-derived factor 1 (SDF-1) expression has been shown to be involved in the development and progression of various malignancies. Our present study aims to investigate the clinical and prognostic value of SDF-1 expression and improve risk stratification in patients with gastric cancer. Peritumoral and intratumoral SDF-1 levels were assessed in 220 retrospectively enrolled gastric cancer patients, and their relations with clinicopathological features and clinical outcomes were evaluated. A predictive nomogram was created to refine risk stratification for overall survival of gastric cancer patients. Compared with peritumor tissues, tumor tissues showed decreased SDF-1 expression levels according to TNM stage progression in gastric cancer specimens. Peritumoral SDF-1 expression correlated positively with tumor invasion depth and lymph node metastasis, whereas intratumoral SDF-1 expression associated negatively with tumor size, tumor differentiation, tumor invasion depth, lymph node metastasis, and clinical TNM stage. Moreover, both low peritumoral SDF-1 expression and high intratumoral SDF-1 expression indicated favorable overall survival, and SDF-1 risk derived from the peritumoral/intratumoral SDF-1 expression signature could stratify prognosis of patients with gastric cancer. After backward elimination, SDF-1 risk was identified as an independent prognostic factor for survival. Finally, a predictive nomogram was generated with identified independent prognosticators to assess patient survival at 3 and 5 years following surgery. Conclusively, SDF-1 risk, an identified independent prognostic factor, could be developed into a nomogram with tumor invasion depth, lymph node involvement, and distant metastasis to refine predictive accuracy for survival in patients with gastric cancer after surgical resection.
登录
查看更多内容
影响因子：
29.4
作者：
Karmiris, Konstantinos;Paintaud, Gilles;Rutgeerts, Paul
通讯作者：
Rutgeerts, Paul
影响因子：
4
作者：
Sun, YX;Wang, JC;Taichman, RS
通讯作者：
Taichman, RS
影响因子：
3.7
作者：
He H;Wang C;Shen Z;Fang Y;Wang X;Chen W;Liu F;Qin X;Sun Y
通讯作者：
Sun Y
DOI：
10.1016/s0140-6736(09)60617-6
发表时间：
2009-08-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hartgrink HH;Jansen EP;van Grieken NC;van de Velde CJ
通讯作者：
van de Velde CJ
影响因子：
6.4
作者：
Hassan, Saima;Buchanan, Marguerite;Basik, Mark
通讯作者：
Basik, Mark