Upregulated expression of C-X-C chemokine receptor 4 is an independent prognostic predictor for patients with gastric cancer.
Upregulated expression of C-X-C chemokine receptor 4 is an independent prognostic predictor for patients with gastric cancer.
复制标题
DOI：
10.1371/journal.pone.0071864
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
He H;Wang C;Shen Z;Fang Y;Wang X;Chen W;Liu F;Qin X;Sun Y
趋化因子（C-X-C基序）受体CXCR4在恶性组织中的异常表达已有报道，但其在胃癌预后中的作用尚不清楚。我们的研究旨在探讨CXCR4在胃癌患者中的表达及其预后意义。应用免疫组化方法回顾性分析97例中国胃腺癌患者CXCR4的表达。通过Kaplan-Meier分析评估结果与临床特征和总生存率的相关性。采用Cox回归分析评估CXCR4表达及临床结局的预后价值。采用受试者工作特征（ROC）分析确定结合CXCR4表达的分子预后分层方案。结果表明，CXCR4主要定位于细胞膜和细胞质中。胃癌组织中CXCR4蛋白水平上调，且CXCR4表达上调仅与Lauren分型相关（P<0.001）。胃癌组织中CXCR4表达升高与胃癌患者总生存率差呈正相关（P<0.001）。进一步多因素Cox回归分析提示肿瘤内CXCR4表达是该疾病的独立预后指标。将肿瘤内CXCR4密度的预后价值应用于TNM分期系统，对胃癌患者的预后有较好的预测价值。综上所述，肿瘤内CXCR4表达被认为是胃癌患者总生存期的独立预后指标。在TNM分期的基础上，检测CXCR4的表达有助于预测胃癌患者的预后。
Aberrant chemokine (C-X-C motif) receptor CXCR4 expressions in malignant tissues have been reported, but its role in gastric cancer prognosis remains unknown. Our studies were designed to investigate the expression and prognostic significance of CXCR4 in patients with gastric cancer. CXCR4 expression was retrospectively analyzed by immunohistochemistry in 97 patients with gastric adenocarcinoma from China. Results were assessed for association with clinical features and overall survival by using Kaplan-Meier analysis. Prognostic values of CXCR4 expression and clinical outcomes were evaluated by Cox regression analysis. A molecular prognostic stratification scheme incorporating CXCR4 expression was determined by using receiver operating characteristic (ROC) analysis. The results show that CXCR4 predominantly localized in the cell membranes and cytoplasm. The protein level of CXCR4 was upregulation in gastric cancer tissues and upregulated expression of CXCR4 was only significantly associated with Lauren classification (P<0.001). Increased CXCR4 expression in gastric cancer tissues was positively correlated with poor overall survival of gastric cancer patients (P<0.001). Further multivariate Cox regression analysis suggested that intratumoral CXCR4 expression was an independent prognostic indicator for the disease. Applying the prognostic value of intratumoral CXCR4 density to TNM stage system showed a better prognostic value in patients with gastric cancer. In conclusion, intratumoral CXCR4 expression was recognized as an independent prognostic marker for the overall survival of patients with gastric cancer. On the basis of TNM stage, detection of CXCR4 expression will be helpful for predicting prognosis for patients with gastric cancer.
登录
查看更多内容
影响因子：
120.1
作者：
De Clercq, E
通讯作者：
De Clercq, E
DOI：
10.1007/s10120-005-0320-0
发表时间：
2005-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Yasui, Wataru;Oue, Naohide;Nakayama, Hirofumi
通讯作者：
Nakayama, Hirofumi
影响因子：
9.2
作者：
Sun, Xueqing;Cheng, Guangcun;Hao, Mingang;Zheng, Jianghua;Zhou, Xiaoming;Zhang, Jian;Taichman, Russell S.;Pienta, Kenneth J.;Wang, Jianhua
通讯作者：
Wang, Jianhua
DOI：
10.1016/s0140-6736(09)60617-6
发表时间：
2009-08-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hartgrink HH;Jansen EP;van Grieken NC;van de Velde CJ
通讯作者：
van de Velde CJ
影响因子：
11.5
作者：
Teicher, Beverly A.;Fricker, Simon P.
通讯作者：
Fricker, Simon P.