Relationships Between Plasma Lipoprotein Concentrations and Insulin Action in an Obese Hyperinsulinemic Population
Relationships Between Plasma Lipoprotein Concentrations and Insulin Action in an Obese Hyperinsulinemic Population
复制标题
肥胖高胰岛素血症人群血浆脂蛋白浓度与胰岛素作用之间的关系
DOI：
10.2337/diab.36.8.897
复制
发表时间：
1987
期刊：
影响因子：
7.7
通讯作者：
B. Howard
中科院分区：
文献类型：
--
作者：
W. Abbott;S. Lillioja;A. Young;J. Zawadzki;H. Yki;L. Christin;B. Howard
已经观察到脂蛋白浓度和胰岛素作用之间的关系。这些关系对于解释肥胖、糖尿病和高甘油三酯血症中发现的胰岛素抵抗与脂蛋白代谢异常之间的关联可能很重要。我们测量了 85 名男性和 56 名女性的血浆脂蛋白浓度和胰岛素作用指数，他们的血脂均正常且糖耐量正常。受试者是肥胖的美国西南部印第安人（体重指数 34 ± 1）。通过高胰岛素钳夹并同时进行间接量热法来测量胰岛素作用。甘油三酯浓度与总胰岛素介导的葡萄糖处理率（男性和女性分别为 r = –.37，P < .01；r = –.24，P < .10）、葡萄糖储存（r = –.31，P < .01；r = –.25，P < .10）、葡萄糖氧化增加（r = –.29，P < .01；r = –.24，P < .10）呈负相关。 .10），并且仅在男性中抑制内源性葡萄糖产生（r = –.32，P < .01）。高密度脂蛋白 (HDL) 胆固醇浓度与总胰岛素介导的葡萄糖处理率 (r –.35, P < .01; r = .33, P < .05)、碳水化合物氧化增加 (r = .40, P < .001; r = .39, P < .001)、内源性葡萄糖产生抑制 (r = .24, P < .05; r = .29，P < .05），并且仅在男性中，葡萄糖储存（r = .35，P < .001）。脂蛋白浓度和胰岛素作用之间的关系与肥胖和胰岛素浓度无关（女性HDL胆固醇除外），甘油三酯和HDL胆固醇与胰岛素作用的关系彼此独立。这些关系表明，胰岛素抵抗的发展与与肥胖、非胰岛素依赖型糖尿病和高甘油三酯血症相关的脂蛋白代谢异常之间可能存在联系。
Relationships have been observed between lipoprotein concentrations and insulin action. These relationships may be important in explaining the association of insulin resistance and abnormalities of lipoprotein metabolism found in obesity, diabetes, and hypertriglyceridemia. We have measured plasma lipoprotein concentrations and indices of insulin action in 85 men and 56 women, all of whom were normolipidemic and had normal glucose tolerance. The subjects were obese Southwestern American Indians (body mass index 34 ± 1). Insulin action was measured via the hyperinsulinemic clamp with simultaneous indirect calorimetry. Triglyceride concentrations were inversely related to rates of total insulin-mediated glucose disposal (in men and women, respectively, r = –.37, P < .01; r = –.24, P < .10), glucose storage (r = –.31, P < .01; r = –.25, P < .10), increase in glucose oxidation (r = –.29, P < .01; r = –.24, P < .10), and, in men only, suppression of endogenous glucose production (r = –.32, P < .01). High-density lipoprotein (HDL) cholesterol concentration was positively related to rates of total insulin-mediated glucose disposal (r –.35, P < .01; r = .33, P < .05), increase in carbohydrate oxidation (r = .40, P < .001; r = .39, P < .001), suppression of endogenous glucose production (r = .24, P < .05; r = .29, P < .05), and, in men only, glucose storage (r = .35, P < .001). The relationships between lipoprotein concentrations and insulin action were independent of adiposity and insulin concentrations (with the exception of HDL cholesterol in women), and the relationships of Triglyceride and HDL cholesterol with insulin action were independent of each other. These relationships indicate that there may be a link between the development of insulin resistance and the abnormalities in lipoprotein metabolism associated with obesity, non-insulin-dependent diabetes mellitus, and hypertriglyceridemia.
影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA
血浆胰岛素和脂蛋白浓度：导致动脉粥样硬化的关联？
影响因子：
5
作者：
Orchard,TJ;Becker,DJ;Bates,M;Kuller,LH;Drash,AL
通讯作者：
Drash,AL