Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul.
Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul.
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DOI：
10.3389/fimmu.2018.00739
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发表时间：
2018
影响因子：
7.3
通讯作者：
DeFranco AL
中科院分区：
文献类型：
--
作者：
DeFranco AL
本文描述了我在1979年至1983年期间作为博士后研究员在比尔·保罗实验室所做的工作，并在较小程度上将这项工作与当时和之前不久比尔实验室正在进行的其他B细胞活化和抗体反应的工作联系起来，包括白细胞介素4的发现。此外，这项工作描述了我在自己的实验室中对我直接与比尔合作期间开始的主题进行的后续和持续工作。特别强调的是了解信号的生化机制的B细胞抗原受体（BCR）的内部的B细胞。我实验室的一些研究与林恩调节BCR信号有关，这些研究与格罗斯曼和保罗在1992年及随后提出的淋巴细胞调谐假说有关。
This article describes the work I did in Bill Paul’s lab as a postdoctoral fellow between 1979 and 1983, and to a lesser extent puts that work in the context of other work on B cell activation and antibody responses that was going on in Bill’s lab at that time and shortly beforehand, including the discovery of interleukin 4. In addition, this work describes the subsequent and continuing work in my own lab following-up on themes I began during my time working directly with Bill. A particular emphasis was on understanding the biochemical mechanisms of signaling by the B cell antigen receptor (BCR) to the interior of the B cell. Some of the studies from my lab related to the regulation of BCR signaling by Lyn are described in relationship to the lymphocyte tuning hypothesis put forth by Grossman and Paul in 1992 and subsequently.
DOI：
10.1084/jem.154.4.1100
发表时间：
1981-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Asano Y;Singer A;Hodes RJ
通讯作者：
Hodes RJ
DOI：
10.1084/jem.157.2.657
发表时间：
1983-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Stein KE;Zopf DA;Miller CB;Johnson BM;Mongini PK;Ahmed A;Paul WE
通讯作者：
Paul WE