Perfluorooctane sulfonate affects intestinal immunity against bacterial infection.
Perfluorooctane sulfonate affects intestinal immunity against bacterial infection.
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全氟辛烷磺酸影响肠道抵抗细菌感染的免疫力
DOI：
10.1038/s41598-017-04091-z
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发表时间：
2017-07-12
影响因子：
4.6
通讯作者：
Qiu J
中科院分区：
文献类型：
--
作者：
Suo C;Fan Z;Zhou L;Qiu J
全氟辛烷磺酸（PFOS）是一种环境污染物，在工业中被用作表面活性剂和驱虫剂。全氟辛烷磺酸清除和降解半衰期长，在人体内具有蓄积性，对人体健康具有潜在威胁。先前的研究表明，免疫细胞的发育和功能可能会受到全氟辛烷磺酸的影响。虽然全氟辛烷磺酸很有可能通过口服途径被吸收，但全氟辛烷磺酸是否以及如何影响肠道免疫细胞尚不清楚。本研究采用小鼠柠檬酸杆菌感染模型，研究了PFOS对小鼠肠道免疫功能的影响。我们发现，在感染的早期阶段，PFOS抑制病原体的扩张，通过促进IL-22的产生从第3组先天淋巴细胞（ILC 3）在芳烃受体依赖的方式。尽管如此，对小鼠持续进行全氟辛烷磺酸治疗最终导致无法完全清除病原体。在感染后期，PFOS处理小鼠的细菌计数增加，伴随着炎症细胞因子增加、粘蛋白产生减少和生态失调，其特征是干酪乳杆菌、约翰逊乳杆菌水平下降，E.杆菌我们的研究揭示了全氟辛烷磺酸积累引起的肠道细菌感染的有害后果。
Perfluorooctane sulfonate (PFOS) is an environmental contaminant that has been manufactured to be used as surfactants and repellents in industry. Due to long half-life for clearance and degradation, PFOS is accumulative in human body and has potential threat to human health. Previous studies have shown the development and function of immune cells can be affected by PFOS. Although PFOS has a high chance of being absorbed through the oral route, whether and how PFOS affects immune cells in the gut is unknown. Using mouse model ofCitrobacter rodentiuminfection, we investigated the role of PFOS on intestinal immunity. We found at early phase of the infection, PFOS inhibited the expansion of the pathogen by promoting IL-22 production from the group 3 innate lymphoid cell (ILC3) in an aryl hydrocarbon receptor dependent manner. Nevertheless, persistent PFOS treatment in mice finally led to a failure to clear the pathogen completely. At late phase of infection, enhanced bacterial counts in PFOS treated mice were accompanied by increased inflammatory cytokines, reduced mucin production and dysbiosis, featured by decreased level ofLactobacillus casei,Lactobacillus johnsoniiand increasedE. coli. Our study reveals a deleterious consequence in intestinal bacterial infection caused by PFOS accumulation.
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影响因子：
6.7
作者：
Bergstrom KS;Kissoon-Singh V;Gibson DL;Ma C;Montero M;Sham HP;Ryz N;Huang T;Velcich A;Finlay BB;Chadee K;Vallance BA
通讯作者：
Vallance BA
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
--
作者：
Ferreira, P. C. D.;da Silva, J. B.;Oliveira, M. L. S.
通讯作者：
Oliveira, M. L. S.
影响因子：
30.5
作者：
Lee, Jacob S.;Cella, Marina;McDonald, Keely G.;Garlanda, Cecilia;Kennedy, Gregory D.;Nukaya, Manabu;Mantovani, Alberto;Kopan, Raphael;Bradfield, Christopher A.;Newberry, Rodney D.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
3.1
作者：
Chan, Justin M.;Bhinder, Ganive;Vallance, Bruce A.
通讯作者：
Vallance, Bruce A.