Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates.
Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates.
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DOI：
10.1038/s41467-023-37059-x
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发表时间：
2023-03-23
影响因子：
16.6
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
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作者：
Uraki, Ryuta;Iida, Shun;Halfmann, Peter J.;Yamayoshi, Seiya;Hirata, Yuichiro;Iwatsuki-Horimoto, Kiyoko;Kiso, Maki;Ito, Mutsumi;Furusawa, Yuri;Ueki, Hiroshi;Sakai-Tagawa, Yuko;Kuroda, Makoto;Maemura, Tadashi;Kim, Taksoo;Mine, Sohtaro;Iwamoto, Noriko;Li, Rong;Liu, Yanan;Larson, Deanna;Fukushi, Shuetsu;Watanabe, Shinji;Maeda, Ken;Wang, Zhongde;Ohmagari, Norio;Theiler, James;Fischer, Will;Korber, Bette;Imai, Masaki;Suzuki, Tadaki;Kawaoka, Yoshihiro
2022 年夏季，Omicron 亚变体 BA.2.75 的流行率在印度和尼泊尔迅速增加，并在全球蔓延。然而，BA.2.75 的病毒学特征很大程度上未知。在这里，我们评估了 BA.2.75 临床分离株在叙利亚仓鼠中的复制能力和致病性。虽然我们发现感染 BA.2、BA.5 或 BA.2.75 的仓鼠体重变化没有显着差异，但 BA.2.75 在肺部的复制能力高于 BA.2 和 BA.5。值得注意的是，BA.2.75 在仓鼠中引起局灶性病毒性肺炎，其特征是肺泡区域散布斑片状炎症，而在 BA.5 感染的仓鼠中未观察到这种情况。此外，在竞争测定中，BA.2.75 在仓鼠肺部的复制效果优于 BA.5。这些结果表明，在仓鼠模型中，BA.2.75 可导致比 BA.5 和 BA.2 更严重的呼吸道疾病，应密切监测。 Omicron 亚变体的复制适应性和引起更严重疾病的可能性可能有所不同。在这项研究中，作者在仓鼠模型中对 Omicron BA.2.75 进行了表征，发现它在肺部的复制效率比 BA.2 和 BA.5 更高。
The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological features of BA.2.75 are largely unknown. Here, we evaluated the replicative ability and pathogenicity of BA.2.75 clinical isolates in Syrian hamsters. Although we found no substantial differences in weight change among hamsters infected with BA.2, BA.5, or BA.2.75, the replicative ability of BA.2.75 in the lungs is higher than that of BA.2 and BA.5. Of note, BA.2.75 causes focal viral pneumonia in hamsters, characterized by patchy inflammation interspersed in alveolar regions, which is not observed in BA.5-infected hamsters. Moreover, in competition assays, BA.2.75 replicates better than BA.5 in the lungs of hamsters. These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2 in a hamster model and should be closely monitored. Omicron subvariants may differ in their replicative fitness and their potential to cause more severe disease. In this study, the authors characterized Omicron BA.2.75 in a hamster model and found that it replicates more efficiently in the lungs than BA.2 and BA.5.
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DOI：
10.1038/s41577-022-00676-6
发表时间：
2022-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Flemming A
通讯作者：
Flemming A
影响因子：
5.4
作者：
Dagotto, Gabriel;Mercado, Noe B.;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
影响因子：
64.8
作者：
Meng B;Abdullahi A;Ferreira IATM;Goonawardane N;Saito A;Kimura I;Yamasoba D;Gerber PP;Fatihi S;Rathore S;Zepeda SK;Papa G;Kemp SA;Ikeda T;Toyoda M;Tan TS;Kuramochi J;Mitsunaga S;Ueno T;Shirakawa K;Takaori-Kondo A;Brevini T;Mallery DL;Charles OJ;CITIID-NIHR BioResource COVID-19 Collaboration;Genotype to Phenotype Japan (G2P-Japan) Consortium;Ecuador-COVID19 Consortium;Bowen JE;Joshi A;Walls AC;Jackson L;Martin D;Smith KGC;Bradley J;Briggs JAG;Choi J;Madissoon E;Meyer KB;Mlcochova P;Ceron-Gutierrez L;Doffinger R;Teichmann SA;Fisher AJ;Pizzuto MS;de Marco A;Corti D;Hosmillo M;Lee JH;James LC;Thukral L;Veesler D;Sigal A;Sampaziotis F;Goodfellow IG;Matheson NJ;Sato K;Gupta RK
通讯作者：
Gupta RK
影响因子：
64.5
作者：
Korber, Bette;Fischer, Will M.;Montefiori, David C.
通讯作者：
Montefiori, David C.
DOI：
10.1016/j.ajpath.2022.01.007
发表时间：
2022-04
期刊：
The American journal of pathology
影响因子：
--
作者：
Christensen PA;Olsen RJ;Long SW;Snehal R;Davis JJ;Ojeda Saavedra M;Reppond K;Shyer MN;Cambric J;Gadd R;Thakur RM;Batajoo A;Mangham R;Pena S;Trinh T;Kinskey JC;Williams G;Olson R;Gollihar J;Musser JM
通讯作者：
Musser JM