Multiscale Study on Hemodynamics in Patient-Specific Thoracic Aortic Coarctation
Multiscale Study on Hemodynamics in Patient-Specific Thoracic Aortic Coarctation
复制标题
特定患者胸主动脉缩窄血流动力学的多尺度研究
DOI：
10.1007/978-3-642-54268-8_7
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Aike Qiao
中科院分区：
文献类型：
--
作者：
Wenyu Fu;Fan Bai;Ren Xiaochen;Aike Qiao
在这项挑战中，我们打算通过使用0 D-3D连接的多尺度模型来模拟患者的心血管系统。多尺度分析的目的是找到合适的边界条件无名动脉（IA），左颈总动脉（LCA）和左锁骨下动脉（LSA）的局部三维计算流体动力学模拟。首先，建立了患者循环系统的集总参数模型（LPM），该模型可以通过调节心脏的弹性功能和外周阻力等参数来模拟静息和应激条件，因为施用的是普肾上腺素导致患者的心率和外周阻力变化。其次，在LPM中的参数值略有修改，以符合以下条件：1。提供了压力和流速曲线，2.提供AcsAo、IA、LCA和LSA的血液分布比。最后，我们得到了IA，LCA和LSA的出口条件，然后连接在每个时间步的0 D模型和3D模型。通过多尺度耦合模拟，得到了流场的流线、收缩压降、压力梯度等参数。
In this challenge, we intended to mimic the patient’s cardiovascular system by using 0D-3D connected multiscale model. The purpose of the multiscale analysis is to find out the appropriate boundary conditions of the innominate artery (IA), left common carotid artery (LCA) and left subclavian artery (LSA) in the local 3D computational fluid dynamics simulation. Firstly, a lumped parameter model(LPM) of the patient’s circulatory system was established which could mimic both the rest and stress conditions by adjusting parameters like elastance function of the heart and the peripheral resistance, since that administering is oprenaline leads to the patient’s heart beat rate and peripheral resistance changes. Secondly, the values of parameters in the LPM were slightly revised to match the following conditions: 1. provided pressure and flow rate curves, 2. provided blood distribution ratio of the AcsAo, IA, LCA and LSA. Finally, we got the outlet conditions of the IA, LCA and LSA, and then connecting the 0D model and the 3D model at each time step. As the results, we got the streamlines, pressure drop through the coarctation, pressure gradient, and some other parameters by coupled multiscale simuation.
影响因子：
4.1
作者：
Moghadam, Mahdi Esmaily;Vignon-Clementel, Irene E.;Marsden, Alison L.
通讯作者：
Marsden, Alison L.
影响因子：
2.4
作者：
Migliavacca, F;Dubini, G;de Leval, MR
通讯作者：
de Leval, MR