Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum.
Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum.
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DOI：
10.1016/j.biopsych.2012.02.024
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发表时间：
2012-09-01
影响因子：
10.6
通讯作者：
Janak, Patricia H.
中科院分区：
文献类型：
--
作者：
Corbit, Laura H.;Nie, Hong;Janak, Patricia H.
成瘾的定义是对行为失去灵活的控制。反应习惯的发展可能反映了行为控制的早期变化。接下来的实验考察了在不同时间的自我给药训练后寻找酒精的灵活性，并测试了背纹状体在控制灵活和习惯性酒精自我给药中的作用。大鼠被训练用杠杆按压来获得不加糖的乙醇（10%）。在不同数量的训练（1,2,4和8周）之后，通过在灭绝测试之前预喂大鼠乙醇或蔗糖来评估杠杆按压反应对贬值的敏感性。随后，我们使用可逆失活技术（巴氯芬/muscimol: 1.0/0.1mM，每侧0.3μl）测试了背内侧纹状体（DMS）和背外侧纹状体（DLS）在控制酒精寻求中的作用。我们发现，在训练早期，操作性对乙醇的反应是目标导向的，并因贬值而降低，但在8周的日常操作性训练后，控制已经转移到一个基于习惯的系统，不再对贬值敏感。此外，经过相对有限的训练，当反应对贬值敏感时，DMS的失活大大减弱了寻求酒精的反应，而DLS的失活则没有效果。相比之下，在8周训练后对贬值不敏感的反应在DLS失活后变得对贬值敏感，但不受DMS失活的影响。这些实验表明，长时间的酒精自我摄入会产生类似习惯的反应，并且在整个训练过程中，反应控制从DMS转移到DLS。
Addictions are defined by a loss of flexible control over behavior. The development of response habits may reflect early changes in behavioral control. The following experiments examined the flexibility of alcohol-seeking following different durations of self-administration training and tested the role of the dorsal striatum in the control of flexible and habitual alcohol self-administration. Rats were trained to lever-press to earn unsweetened ethanol (10%). The sensitivity of the lever-press response to devaluation was assessed by prefeeding the rats either ethanol or sucrose prior to an extinction test following different amounts of training (1,2,4, and 8 weeks). We subsequently tested the role of the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) in controlling alcohol seeking using reversible inactivation techniques (baclofen/muscimol: 1.0/0.1mM, 0.3μl per side). We find that operant responding for ethanol early in training is goal-directed and reduced by devaluation, but after 8 weeks of daily operant training, control has shifted to a habit-based system no longer sensitive to devaluation. Further, following relatively limited training, when responding is sensitive to devaluation, inactivation of the DMS greatly attenuates the alcohol-seeking response whereas inactivation of the DLS is without effect. In contrast, responding that is insensitive to devaluation following 8 weeks of training becomes sensitive to devaluation following inactivation of the DLS, but unaffected by inactivation of the DMS. These experiments demonstrate that extended alcohol self-administration produces habit-like responding and that response control shifts from the DMS to the DLS across the course of training.
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DOI：
10.1523/jneurosci.2243-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jeanblanc J;He DY;Carnicella S;Kharazia V;Janak PH;Ron D
通讯作者：
Ron D
影响因子：
5.3
作者：
Jeanblanc, J;He, DY;Ron, D
通讯作者：
Ron, D
影响因子：
64.8
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
通讯作者：
Graybiel, AM
DOI：
10.1080/14640748308400912
发表时间：
1983-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
DICKINSON, A;NICHOLAS, DJ;ADAMS, CD
通讯作者：
ADAMS, CD
DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD;DICKINSON, A
通讯作者：
DICKINSON, A