Plasmalogen lipids: functional mechanism and their involvement in gastrointestinal cancer.
Plasmalogen lipids: functional mechanism and their involvement in gastrointestinal cancer.
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DOI：
10.1186/s12944-018-0685-9
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发表时间：
2018-03-07
影响因子：
4.5
通讯作者：
de Oliveira Carvalho P
中科院分区：
文献类型：
--
作者：
Messias MCF;Mecatti GC;Priolli DG;de Oliveira Carvalho P
缩醛磷脂是一类甘油磷脂，其在甘油主链中分别在sn-1和sn-2位含有乙烯基醚和酯键。它们占人体磷脂总质量的10mol%，主要作为膜结构组分。缩醛磷脂对于参与细胞信号传导的脂筏微区和富含胆固醇的膜区域的组织和稳定性是重要的。除了它们的结构作用外，醚脂质的一个子集被认为具有内源性抗氧化剂的功能，并且新兴的研究表明它们参与细胞分化和信号传导途径。虽然缩醛磷脂的临床意义与过氧化物酶体疾病有关，但其病理生理作用及其可能的代谢途径尚未完全了解，因为它们为不同组织类型提供了独特的结构属性。研究表明，血浆酶原代谢的变化可能有助于各种类型癌症的发展。在这里，我们回顾了缩醛磷脂的分子特征，以显着增加我们的了解缩醛磷脂分子及其参与胃肠道癌症以及其他类型的癌症。本文的在线版本（10.1186/s12944-018-0685-9）包含补充材料，可供授权用户使用。
The plasmalogens are a class of glycerophospholipids which contain a vinyl-ether and an ester bond at the sn-1 and sn-2 positions, respectively, in the glycerol backbone. They constitute 10 mol% of the total mass of phospholipids in humans, mainly as membrane structure components. Plasmalogens are important for the organization and stability of lipid raft microdomains and cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Although the clinical significance of plasmalogens is linked to peroxisomal disorders, the pathophysiological roles and their possible metabolic pathways are not fully understood since they present unique structural attributes for the different tissue types. Studies suggest that changes in plasmalogen metabolism may contribute to the development of various types of cancer. Here, we review the molecular characteristics of plasmalogens in order to significantly increase our understanding of the plasmalogen molecule and its involvement in gastrointestinal cancers as well as other types of cancers. The online version of this article (10.1186/s12944-018-0685-9) contains supplementary material, which is available to authorized users.
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影响因子：
3.9
作者：
Flasinski, Michal;Hac-Wydro, Katarzyna;Dynarowicz-Latka, Patrycja
通讯作者：
Dynarowicz-Latka, Patrycja
影响因子：
7.4
作者：
Fhaner, Cassie J.;Liu, Sichang;Ji, Hong;Simpson, Richard J.;Reid, Gavin E.
通讯作者：
Reid, Gavin E.
DOI：
10.1073/pnas.1310894110
发表时间：
2013-09-10
影响因子：
11.1
作者：
Benjamin, Daniel I.;Cozzo, Alyssa;Nomura, Daniel K.
通讯作者：
Nomura, Daniel K.
影响因子：
3.9
作者：
Engelmann, B
通讯作者：
Engelmann, B
DOI：
10.5702/massspectrometry.s0015
发表时间：
2013-01-01
期刊：
Mass spectrometry (Tokyo, Japan)
影响因子：
--
作者：
Fhaner, Cassie J;Liu, Sichang;Reid, Gavin E
通讯作者：
Reid, Gavin E