Inhibition of adhesion of Haemophilus influenzae to buccal cells by respiratory secretions
Inhibition of adhesion of Haemophilus influenzae to buccal cells by respiratory secretions
复制标题
通过呼吸道分泌物抑制流感嗜血杆菌与口腔细胞的粘附
作者：
D. Taylor;A. Cripps;R. Clancy
已检查了慢性支气管炎患者的唾液分泌物和痰液抑制非血清型流感嗜血杆菌粘附于人颊上皮细胞的能力。特异性H.通过酶联免疫吸附试验（ELISA）测定流感病毒抗体。唾液和痰液中抗H抗体水平流感病毒免疫球蛋白A（伊加）抗体与口腔细胞粘附呈负相关（r =-0.92）。用H.流感病毒去除了ELISA检测到的抗体，但仅部分去除了对细菌附着的抑制。有支气管炎反复发作史的患者在吸收分泌型伊加（sIgA）特异性抗体后，其抑制活性显著高于对急性感染抵抗的患者（P <0.05）。这些观察结果表明，除了sIgA。存在于呼吸道分泌物中，能够调节H。流感病毒附着于颊上皮细胞。
The ability of salivary secretions and sputum sol from patients with chronic bronchitis to inhibit the adhesion of non‐serotypable Haemophilus influenzae to human buccal epithelial cells has been examined. Specific H. influenzae antibodies were measured by an enzyme‐linked immunosorbent assay (ELISA). Saliva and sputum levels of anti‐ H. influenzae immunoglobulin A (IgA) antibody were related inversely to buccal cell adherence (r = ‐ 0·92). Absorption of saliva and sputum sol with H. influenzae removed antibody detected by ELISA but only partially removed inhibition of attachment of bacteria. In patients with a history of recurrent bronchitis significantly more inhibitory activity remained after absorption of the secretory IgA (sIgA) specific antibody compared with patients who were resistant to acute episodes of infection (P <0·05). These observations suggest that factors, other than sIgA. are present in respiratory secretions and are capable of modulating H. influenzae attachment to buccal epithelial cells.
影响因子：
6.4
作者：
BEACHEY, EH
通讯作者：
BEACHEY, EH
分泌型 IgA 和唾液凝集素的细菌凝集特性。
影响因子：
--
作者：
Rundegren,JL;Arnold,RR
通讯作者：
Arnold,RR