Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma.
Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma.
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DOI：
10.1186/s12943-018-0790-4
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发表时间：
2018-02-19
期刊：
影响因子：
37.3
通讯作者：
Abdel-Rahman O
中科院分区：
文献类型：
--
作者：
Kashyap MK;Abdel-Rahman O
食管癌是最常见的癌症类型之一，是全世界癌症相关死亡的主要原因。根据组织学行为，它主要有两种类型：（i）食管鳞状细胞癌（ESCC）和（ii）食管腺癌（EAD或EAC）。在绝大多数恶性肿瘤中，受体酪氨酸激酶（RTK）被认为在细胞增殖、迁移和转移中起重要作用。翻译后修饰（PTMs）包括酪氨酸激酶（TK）结构域的酪氨酸（pY）残基的磷酸化已被开发用于治疗不同的恶性肿瘤。EGFR的pY残基已被用于肺腺癌患者的治疗目的的肺癌，但我们没有在ESCC患者中进行适当的研究和分类的数据。因此，本综述的目的是总结对ESCC进行的研究，以探讨RTK，酪氨酸激酶抑制剂的作用，其治疗ESCC患者的相关性和后果。
Esophageal cancer is one of the most common types of cancer, which is a leading cause of cancer-related death worldwide. Based on histological behavior, it is mainly of two types (i) Esophageal squamous cell carcinoma (ESCC), and (ii) esophageal adenocarcinoma (EAD or EAC). In astronomically immense majority of malignancies, receptor tyrosine kinases (RTKs) have been kenned to play a consequential role in cellular proliferation, migration, and metastasis of the cells. The post-translational modifications (PTMs) including phosphorylation of tyrosine (pY) residue of the tyrosine kinase (TK) domain have been exploited for treatment in different malignancies. Lung cancer where pY residues of EGFR have been exploited for treatment purpose in lung adenocarcinoma patients, but we do not have such kind of felicitously studied and catalogued data in ESCC patients. Thus, the goal of this review is to summarize the studies carried out on ESCC to explore the role of RTKs, tyrosine kinase inhibitors, and their pertinence and consequentiality for the treatment of ESCC patients.
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影响因子：
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