Mapping of panda plumage color locus on the microsatellite linkage map of the Japanese quail.
Mapping of panda plumage color locus on the microsatellite linkage map of the Japanese quail.
复制标题
日本鹌鹑微卫星连杆地图上的熊猫羽毛颜色基因座的映射。
DOI：
10.1186/1471-2156-7-2
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发表时间：
2006-01-12
期刊：
影响因子：
2.9
通讯作者：
Ito S
中科院分区：
文献类型：
--
作者：
Miwa M;Inoue-Murayama M;Kobayashi N;Kayang BB;Mizutani M;Takahashi H;Ito S
大熊猫(S)是一种常染色体隐性突变，在日本鹌鹑(Coturnix Japan Onica)中表现为整体白色羽毛，带有野生型羽毛斑点。在以往的研究中，S基因座与定位在鸡4号染色体上的血清白蛋白(Alb)和维生素D结合蛋白(GC)属于同一连锁群。本研究通过连锁分析，将S基因座定位在日本鸣禽的微卫星连锁图谱上。S基因座的分离数据来自三代(n=106)。对3个家系中的2个日本鹌鹑4号染色体微卫星标记(CJA04)和3个GGA4微卫星标记进行了基因分型。我们在CJA04上将S基因座定位在GUJ0026和ABR0544之间。通过与鸡的比较定位，该基因定位于GGA4的10.0Mb-14.5Mb区域。在该区域内，内皮素受体B亚型2基因(EDNRB2)被定位，该基因是哺乳动物内皮素受体B基因(EDNRB)的鸟类特异性同源基因。由于EDNRB2基因负责小鼠、大鼠和马的无神经节细胞巨噬细胞和斑点毛色，因此EDNRB2基因被认为是S基因座的候选基因。将S基因座和5个微卫星标记定位在日本鸣禽的CJA04上。提示EDNRB2基因是S基因座的候选基因。
Panda (s) is an autosomal recessive mutation, which displays overall white plumage color with spots of wild-type plumage in the Japanese quail (Coturnix japonica). In a previous study, the s locus was included in the same linkage group as serum albumin (Alb) and vitamin-D binding protein (GC) which are mapped on chicken (Gallus gallus) chromosome 4 (GGA4). In this study, we mapped the s locus on the microsatellite linkage map of the Japanese quail by linkage analysis. Segregation data on the s locus were obtained from three-generation families (n = 106). Two microsatellite markers derived from the Japanese quail chromosome 4 (CJA04) and three microsatellite markers derived from GGA4 were genotyped in the three-generation families. We mapped the s locus between GUJ0026 and ABR0544 on CJA04. By comparative mapping with chicken, this locus was mapped between 10.0 Mb and 14.5 Mb region on GGA4. In this region, the endothelin receptor B subtype 2 gene (EDNRB2), an avian-specific paralog of the mammalian endothelin receptor B gene (EDNRB), is located. Because EDNRB is responsible for aganglionic megacolon and spot coat color in mouse, rat and equine, EDNRB2 is suggested to be a candidate gene for the s locus. The s locus and the five microsatellite markers were mapped on CJA04 of the Japanese quail. EDNRB2 was suggested to be a candidate gene for the s locus.
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影响因子：
2.4
作者：
Inoue-Murayama, M;Kayang, BB;Ito, S
通讯作者：
Ito, S
DOI：
10.1073/pnas.95.6.3024
发表时间：
1998-03-17
影响因子：
11.1
作者：
Lecoin, L;Sakurai, T;Le Douarin, NM
通讯作者：
Le Douarin, NM
影响因子：
4.4
作者：
Minvielle F;Kayang BB;Inoue-Murayama M;Miwa M;Vignal A;Gourichon D;Neau A;Monvoisin JL;Ito S
通讯作者：
Ito S
影响因子：
2.4
作者：
Takahashi, H;Tsudzuki, M;Minezawa, M
通讯作者：
Minezawa, M
DOI：
10.1073/pnas.93.2.867
发表时间：
1996-01-23
影响因子：
11.1
作者：
Gariepy, CE;Cass, DT;Yanagisawa, M
通讯作者：
Yanagisawa, M