The preventive effect of internet-based cognitive behavioral therapy for prevention of depression during pregnancy and in the postpartum period (iPDP): a large scale randomized controlled trial.
The preventive effect of internet-based cognitive behavioral therapy for prevention of depression during pregnancy and in the postpartum period (iPDP): a large scale randomized controlled trial.
复制标题
DOI：
10.1111/pcn.13458
复制
发表时间：
2022-11
影响因子：
11.9
通讯作者：
Kawakami, Norito
中科院分区：
文献类型：
--
作者：
Nishi, Daisuke;Imamura, Kotaro;Watanabe, Kazuhiro;Obikane, Erika;Sasaki, Natsu;Yasuma, Naonori;Sekiya, Yuki;Matsuyama, Yutaka;Kawakami, Norito
关键词：
从产前阶段开始预防围产期抑郁症至关重要。因此，本研究旨在调查最近开发的互联网传递认知行为疗法（iCBT）在妊娠晚期和产后3个月预防重度抑郁发作（MDE）的有效性。这是一项双组、平行组、一般信息对照、随机对照试验。参与者为5017名妊娠16-20周的孕妇，基线时无MDE。他们被随机分配到iCBT（干预; n = 2509）或一般信息（对照; n = 2508）组，按基线时的心理困扰分层。主要结局是使用世界卫生组织复合国际诊断访谈3.0在妊娠32周和产后3个月测量的新发MDE发作的数量。随访期间，干预组59例受试者（2.35%）和对照组73例受试者（2.91%）报告了新发MDE发作。与对照组相比，干预组MDE的风险比（HR）为0.85（95%CI 0.61-1.20），差异无统计学意义。在基线时K6评分在5 - 8之间的参与者中，干预组有10例（1.37%）报告新发MDE，而对照组有28例（3.81%），MDE的HR为0.38（95%CI 0.19-0.79）。未发现iCBT在预防围生期MDE新发方面的干预效果。iCBT可能只在有阈下抑郁症状的孕妇中预防围产期抑郁症。试验注册号：UMIN 000038190。
Prevention of perinatal depression beginning from the antenatal period is essential. Therefore, this study aimed to investigate the effectiveness of recently developed internet‐delivered cognitive behavioral therapy (iCBT) for preventing the onset of a major depressive episode (MDE) in the third trimester and at 3 months postpartum. This is a two‐arm, parallel‐group, general‐information controlled, randomized controlled trial. Participants were 5017 pregnant women at 16–20 weeks' gestation without MDE at baseline. They were randomly assigned to an iCBT (intervention; n = 2509) or general‐information (control; n = 2508) group, stratified by psychological distress at baseline. The primary outcomes were the numbers of new MDE onsets, measured using the World Health Organization Composite International Diagnostic Interview 3.0, at 32 weeks' gestation and at 3 months postpartum. New MDE onset was reported by 59 participants (2.35%) in the intervention group and 73 (2.91%) in the control group during follow‐up. Compared with the control group, the hazard ratio (HR) of MDE in the intervention group was 0.85 (95% CI 0.61–1.20), which was not significantly different. Among participants who scored between 5 and 8 on K6 at baseline, 10 (1.37%) in the intervention group reported new onset of MDE, compared with 28 (3.81%) in the control group, and the HR of MDE was 0.38 (95%CI 0.19–0.79). No intervention effect was found for iCBT in preventing new onset of perinatal MDE. iCBT might prevent perinatal depression only among pregnant women with subthreshold depressive symptoms. Trial registration: UMIN000038190.
登录
查看更多内容
影响因子：
4.6
作者：
Imamura K;Tran TTT;Nguyen HT;Sasaki N;Kuribayashi K;Sakuraya A;Bui TM;Nguyen AQ;Nguyen QT;Nguyen NT;Nguyen KT;Nguyen GTH;Tran XTN;Truong TQ;Zhang MW;Minas H;Sekiya Y;Watanabe K;Tsutsumi A;Kawakami N
通讯作者：
Kawakami N
影响因子：
4.1
作者：
Fairburn, Christopher G.;Patel, Vikram
通讯作者：
Patel, Vikram
DOI：
10.1097/01.chi.0000184930.18552.4d
发表时间：
2006-02-01
影响因子：
13.3
作者：
Leech, SL;Larkby, CA;Day, NL
通讯作者：
Day, NL
DOI：
10.1016/j.invent.2015.06.002
发表时间：
2015-09-01
期刊：
Internet interventions
影响因子：
--
作者：
Barrera, Alinne Z;Wickham, Robert E;Munoz, Ricardo F
通讯作者：
Munoz, Ricardo F
影响因子：
105.7
作者：
Campbell, Marion K.;Piaggio, Gilda;Altman, Douglas G.
通讯作者：
Altman, Douglas G.