C-Kit, a Double-Edged Sword in Liver Regeneration and Diseases.
C-Kit, a Double-Edged Sword in Liver Regeneration and Diseases.
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C-Kit，肝脏再生和疾病的双刃剑
DOI：
10.3389/fgene.2021.598855
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发表时间：
2021
影响因子：
3.7
通讯作者：
Zheng M
中科院分区：
文献类型：
--
作者：
Wang W;Shui L;Liu Y;Zheng M
先前的研究报道了c-kit在胚胎发生和成年期的重要作用。SCF/KIT信号转导通路的激活通常与细胞增殖、迁移和存活有关，从而影响造血、色素沉积和精子发生。c-kit在肝脏中的作用是有争议的，但有人认为它在肝脏再生和疾病中是一把双刃剑。首先，肝c-kit+细胞，包括卵圆细胞、胆汁上皮细胞和部分肝细胞，根据肝损伤的类型，通过再生靶细胞参与肝组织修复。同时，c-kit+肥大细胞在循环中作为未成熟祖细胞，在肝纤维化中起关键作用。此外，c-kit也是一个原癌基因。值得注意的是，c-kit过表达调节胃肠道间质瘤。关于c-kit和肝细胞癌的研究已经有很多，然而，c-kit在肝脏中的复杂作用在很大程度上还没有得到充分的研究。在此，我们广泛总结了以往的研究，旨在为未来的临床和基础研究提供线索。
Previous studies have reported an important role of c-kit in embryogenesis and adulthood. Activation of the SCF/KIT signal transduction pathway is customarily linked to cell proliferation, migration and survival thus influence hematopoiesis, pigmentation, and spermatogenesis. The role of c-kit in the liver is controversial, it is however argued that it is a double-edged sword in liver regeneration and diseases. First, liver c-kit+ cells, including oval cells, bile epithelial cells, and part of hepatocytes, participate in liver tissue repair by regenerating target cells according to the type of liver injury. At the same time, c-kit+ mast cells, act as immature progenitors in circulation, playing a critical role in liver fibrosis. Furthermore, c-kit is also a proto-oncogene. Notably, c-kit overexpression regulates gastrointestinal stromal tumors. Various studies have explored on c-kit and hepatocellular carcinoma, nevertheless, the intricate roles of c-kit in the liver are largely understudied. Herein, we extensively summarize previous studies geared toward providing hints for future clinical and basic research.
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