Oxidized LDL-induced apoptosis.
Oxidized LDL-induced apoptosis.
复制标题
氧化 LDL 诱导细胞凋亡。
DOI：
10.1007/0-306-47931-1_7
复制
发表时间：
2002
影响因子：
--
通讯作者：
A. Nègre
中科院分区：
文献类型：
--
作者：
H. Benoist;R. Salvayre;A. Nègre
现在有大量证据表明，血管壁中产生的 oxLDL 和脂质过氧化产物可以引发与动脉粥样硬化有关的促炎和病理事件。据D. Hajjar和M. Haberland报道，oxLDL应被视为真正的分子“特洛伊木马”或“细胞破坏者”，携带大量脂质过氧化的生物反应产物，其改变细胞功能，诱导细胞内氧化应激，触发多重且相互矛盾的细胞信号传导和转录因子，并最终通过凋亡或坏死诱导细胞死亡。迄今为止，oxLDL 触发并导致病理生理事件的信号传导机制仅得到部分了解。 oxLDL介导的细胞凋亡可能参与动脉粥样硬化的进展，以及随后的斑块破裂和血栓形成事件，最终导致急性心血管疾病。在培养的细胞中，抗氧化剂抑制 LDL 氧化和 oxLDL 的生物效应，例如诱导细胞凋亡，但它们有效预防血管疾病和诱导已形成病变消退的能力仍有待确定。总之，阐明细胞介导的低密度脂蛋白氧化的机制以及脂质过氧化产物引起的细胞功能障碍非常重要，以便确定有效阻断和预防动脉粥样硬化过程的新治疗策略，动脉粥样硬化过程一直是西方国家死亡的主要原因。
There is now substantial evidence establishing that oxLDL and lipid peroxidation products generated in the vascular wall, can elicit proinflammatory and pathological events involved in atherosclerosis. As reported by D. Hajjar and M. Haberland, the oxLDL should be considered as true molecular “Trojan Horses” or “cellular saboteurs” bearing a lot of bioreactive products of lipid peroxidation, that modify cell functions, induce intracellular oxidative stress, trigger multiple and contradictatory cell signalings and transcription factors, and finally induce cell death by apoptosis or necrosis. To date, the signaling mechanisms triggered by oxLDL and leading to physiopathological events, are only partly understood. The oxLDL-mediated apoptosis may participate in the progression of atherosclerosis, and in subsequent plaque rupture and thrombotic events which lead finally to acute cardiovascular diseases. In cultured cells antioxidants inhibit LDL oxidation and biological effect of oxLDL, such as apoptosis induction, but their ability to prevent efficiently vascular diseases and to induce regression of established lesions remains to be established. In conclusion, it is very important to clarify the mechanisms of cell-mediated LDL oxidation, as well as the cellular dysfunctions induced by lipid peroxidation products, in order to define new therapeutic strategies efficient in blocking and preventing the atherosclerotic process which always represent a major cause of death in western countries.
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影响因子：
8.7
作者：
Memon, RA;Staprans, I;Grunfeld, C
通讯作者：
Grunfeld, C
DOI：
10.1016/s0002-9149(98)00808-x
发表时间：
1998-11
期刊：
The American journal of cardiology
影响因子：
--
作者：
P. Kwiterovich
通讯作者：
P. Kwiterovich
影响因子：
6.4
作者：
Khovidhunkit, W;Memon, RA;Grunfeld, C
通讯作者：
Grunfeld, C
DOI：
10.1161/01.atv.20.6.1430
发表时间：
2000-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
M. Wolin
通讯作者：
M. Wolin
DOI：
10.1073/pnas.93.25.14833
发表时间：
1996-12-10
影响因子：
11.1
作者：
Ramprasad, MP;Terpstra, V;Steinberg, D
通讯作者：
Steinberg, D