Unwrapping the unappreciated: recent progress in Remak Schwann cell biology.

Unwrapping the unappreciated: recent progress in Remak Schwann cell biology.
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DOI:
10.1016/j.conb.2017.10.003
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发表时间:
2017-12
影响因子:
5.7
通讯作者:
Monk KR
Monk KR
中科院分区:
医学2区
文献类型:
--
作者:
Harty BL;Monk KR

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雪旺细胞(SC)是周围神经系统(PNS)中髓鞘形成和保护轴突的特化胶质细胞。虽然髓鞘形成SC更常被研究,但PNS也含有多种非髓鞘形成SC,包括但不限于Remak SC(RSC)、终末SC、肠神经胶质。虽然该领域目前缺乏许多强大的工具来询问非髓鞘化SC的功能,但最近的证据表明,与其髓鞘化对应物一样,非髓鞘化SC对于适当的PNS功能至关重要。在这篇综述中,我们特别关注RSC,并强调最近的进展,了解RSC的发展,功能和参与PNS再生的监管机构。
Schwann cells (SCs) are specialized glial cells that myelinate and protect axons in the peripheral nervous system (PNS). Although myelinating SCs are more commonly studied, the PNS also contains a variety of non-myelinating SCs, including but not limited to Remak SCs (RSCs), terminal SCs, enteric glia. While the field currently lacks many robust tools for interrogating the functions of non-myelinating SCs, recent evidence suggests that, like their myelinating counterparts, non-myelinating SCs are critical for proper PNS function. In this review, we focus specifically on RSCs and highlight recent advances in understanding regulators of RSC development, function, and participation in PNS regeneration.
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