Regulation of immune reactivity by intercellular transfer.

Regulation of immune reactivity by intercellular transfer.
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DOI:
10.3389/fimmu.2014.00112
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发表时间:
2014
影响因子:
7.3
通讯作者:
Moser M
Moser M
中科院分区:
医学2区
文献类型:
--
作者:
Dhainaut M;Moser M

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最近提出,T淋巴细胞与APC密切结合,当它们解离时,可以从呈递细胞提取表面分子。这些观察结果质疑表型定义的细胞群体之间的离散相互作用的经典观点。在这篇综述中,我们总结了一些报告表明,在免疫突触的膜交换可以是一个载体的细胞间通信,并设想一些后果的T细胞的生物学。
It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports suggesting that membrane exchange at the immune synapse can be a vector for intercellular communication and envisage some consequences on the biology of T cells.
TC21和RHOG GTPase依赖性吞噬作用介导了免疫突触的T细胞受体内在化。
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