Generation of a human-derived induced pluripotent stem cell line (SIAISi012-A) from an 82-year-old healthy Chinese Han male.

Generation of a human-derived induced pluripotent stem cell line (SIAISi012-A) from an 82-year-old healthy Chinese Han male.
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从 82 岁健康的中国汉族男性中产生人源诱导多能干细胞系 (SIAISi012-A)。

DOI:
10.1016/j.scr.2021.102186
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发表时间:
2021-01
期刊:
影响因子:
1.2
通讯作者:
Ying Wang
Ying Wang
中科院分区:
医学4区
文献类型:
--
作者:
Jinhui Guo;Fang Fang;Qiuting Dai;Wenxin Zhang;Weihao Di;Jiaan Hu;Jian Zhao;Jiumei Cao;Ying Wang

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随着全球人口中位年龄的增加,与衰老相关的神经系统疾病对人类健康构成重大挑战。适当的建模系统可以是有用的工具,以更好地了解与年龄相关的神经元变性疾病的机制。在这里,我们成功地生成了一个82岁健康男性的iPSC衍生的建模系统,这个新建立的系显示所有多能标记都得到了表达,并且通过三系分化证实了分化潜力。STR分析证明了细胞系的同一性,G-结合显示了正常的核型。
As the global median population age increases, neurological diseases associated with aging pose significant challenges to human health. Appropriate modeling systems can be useful tools to better understand the mechanism of age-related neuronal degeneration diseases. Here, we successfully generated an iPSC-derived modeling system of an 82-year-old healthy man, this newly established line showed that all pluripotent markers were expressed, and the differentiation potential was confirmed by trilineage differentiation. STR profiling proved the cell line identity, and G-binding showed the normal karyotype.
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