Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.
Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.
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DOI：
10.1007/s11926-022-01071-9
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发表时间：
2022-06
影响因子：
5
通讯作者：
Allen KD
中科院分区：
文献类型：
--
作者：
Yeater TD;Cruz CJ;Cruz-Almeida Y;Allen KD
自主神经系统是应激反应的重要调节器，并在慢性疼痛状态下表现出功能变化。这篇综述讨论了自主神经失调，骨关节炎（OA）进展和慢性疼痛之间的潜在重叠。在此基础上，我们讨论了临床前到临床研究的机会，以缩小我们对自主神经失调和OA的认识差距。最后，我们考虑通过调节自主神经系统来产生新的OA疼痛疗法的潜力。最近的综述为OA进展中的自主神经系统提供了一个框架;然而，研究仍然局限于该主题。在其他慢性疼痛状态下，中枢自主神经网络和大脑中的疼痛处理中心之间的功能重叠表明两个系统的伴随失调之间的关系。非药物疗法，如迷走神经刺激，正念冥想和运动，已显示出缓解关节疾病疼痛症状的希望，这些干预措施可能部分通过自主神经系统介导。自主神经系统似乎在OA进展中失调，进一步研究重新平衡自主神经功能可能会导致治疗OA疼痛的新治疗策略。
The autonomic nervous system is an important regulator of stress responses and exhibits functional changes in chronic pain states. This review discusses potential overlap among autonomic dysregulation, osteoarthritis (OA) progression, and chronic pain. From this foundation, we then discuss preclinical to clinical research opportunities to close gaps in our knowledge of autonomic dysregulation and OA. Finally, we consider the potential to generate new therapies for OA pain via modulation of the autonomic nervous system. Recent reviews provide a framework for the autonomic nervous system in OA progression; however, research is still limited on the topic. In other chronic pain states, functional overlaps between the central autonomic network and pain processing centers in the brain suggest relationships between concomitant dysregulation of the two systems. Non-pharmacological therapeutics, such as vagus nerve stimulation, mindfulness-based meditation, and exercise, have shown promise in alleviating painful symptoms of joint diseases, and these interventions may be partially mediated through the autonomic nervous system. The autonomic nervous system appears to be dysregulated in OA progression, and further research on rebalancing autonomic function may lead to novel therapeutic strategies for treating OA pain.
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影响因子：
7
作者：
Bannuru, R. R.;Osani, M. C.;McAlindon, T. E.
通讯作者：
McAlindon, T. E.
DOI：
10.1007/s13311-017-0600-5
发表时间：
2018-01
期刊：
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Farzi A;Fröhlich EE;Holzer P
通讯作者：
Holzer P
DOI：
10.1016/j.autneu.2017.09.003
发表时间：
2017-12
期刊：
Autonomic neuroscience : basic & clinical
影响因子：
--
作者：
Adlan AM;Veldhuijzen van Zanten JJCS;Lip GYH;Paton JFR;Kitas GD;Fisher JP
通讯作者：
Fisher JP
影响因子：
3.3
作者：
Cortelli, P.;Giannini, G.;Pierangeli, G.
通讯作者：
Pierangeli, G.
影响因子：
2.3
作者：
Bock K;Plaass C;Coger V;Peck CT;Reimers K;Stukenborg-Colsman C;Claassen L
通讯作者：
Claassen L