Corpus Callosum Shape Analysis with Application to Dyslexia.

Corpus Callosum Shape Analysis with Application to Dyslexia.
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DOI:
10.2478/v10134-010-0017-8
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发表时间:
2010-06
影响因子:
2.1
通讯作者:
Switala AE
Switala AE
中科院分区:
医学4区
文献类型:
--
作者:
Casanova MF;El-Baz A;Elnakib A;Giedd J;Rumsey JM;Williams EL;Switala AE

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胼胝体的形态学研究表明,它参与了一些精神疾病。在本研究中,我们介绍了一种新的模式识别技术,提供了一个逐点的形状描述符的胼胝体。该方法使用电场线的弧长,以避免由折叠解剖轮廓引起的不连续性。我们测试了这种技术,通过比较一系列的阅读障碍男性(n = 16)和年龄匹配的对照组(n = 14)的胼胝体的形状。结果表明,在阅读障碍的胼胝体的大小普遍增加,伴随着减少在其嘴和尾极。报告的形状分析和2D重建提供了解剖学重要性信息,否则在单独分析尺寸信息时会忽略这些信息。
Morphometric studies of the corpus callosum suggest its involvement in a number of psychiatric conditions. In the present study we introduce a novel pattern recognition technique that offers a point-by-point shape descriptor of the corpus callosum. The method uses arc lengths of electric field lines in order to avoid discontinuities caused by folding anatomical contours. We tested this technique by comparing the shape of the corpus callosum in a series of dyslexic men (n = 16) and age-matched controls (n = 14). The results indicate a generalized increase in size of the corpus callosum in dyslexia with a concomitant diminution at its rostral and caudal poles. The reported shape analysis and 2D-reconstruction provide information of anatomical importance that would otherwise passed unnoticed when analyzing size information alone.
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发表时间: 2006-04-01
影响因子: 3.4
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