Fiber ball white matter modeling in focal epilepsy.
Fiber ball white matter modeling in focal epilepsy.
复制标题
局灶性癫痫的纤维球白色物质模型。
DOI：
10.1002/hbm.25382
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发表时间：
2021-06-01
影响因子：
4.8
通讯作者：
Keller SS
中科院分区：
文献类型：
--
作者：
Bryant L;McKinnon ET;Taylor JA;Jensen JH;Bonilha L;de Bezenac C;Kreilkamp BAK;Adan G;Wieshmann UC;Biswas S;Marson AG;Keller SS
多间隔扩散磁共振成像(MRI)方法越来越多地被应用于估计人脑轴突内和轴突外的扩散特征。纤维球成像(FBI)及其扩展的纤维球白质模型(FBWM)就是最近描述的这种多间隔方法。然而，这些特殊的方法还没有在临床队列中应用。对几个具有可解释生物学意义的扩散参数的模拟可能会为癫痫耐药的新的、非侵入性的生物标志物的开发提供依据。在目前的研究中，我们使用FBI和FBWM来评估长期局灶性癫痫患者的白质束轴突内和轴外扩散特性。计算50条脑白质束束长度方向的FBI/FBWM扩散参数，并对难治性癫痫、非难治性癫痫患者和正常对照组进行统计学比较。我们报道，与对照组相比，慢性癫痫患者具有广泛的轴突外扩散，特别是在从丘脑、纹状体、脑干和脚部区域向大脑皮质投射的白质束的限定区域。与非顽固性癫痫患者相比，难治性癫痫患者轴突外扩散的标记物显著增加。本研究中观察到的癫痫患者轴突外扩散性改变可能是神经炎性过程的标志或轴突密度降低的反映，这两种改变在局灶性癫痫中都已得到组织学证实。FBI是一种临床上可行的MRI方法，它为关于脑微结构环境的更具解释性的结论提供了基础，并可能代表癫痫药物耐药性的一个独特的生物标志物。布莱恩特等人。应用纤维球成像测量长期局灶性癫痫患者轴突内和轴外白质扩散。据报道，难治性和非难治性癫痫患者的轴突外扩散不同，可能是一种新的药物耐药的成像生物标志物。
Multicompartment diffusion magnetic resonance imaging (MRI) approaches are increasingly being applied to estimate intra‐axonal and extra‐axonal diffusion characteristics in the human brain. Fiber ball imaging (FBI) and its extension fiber ball white matter modeling (FBWM) are such recently described multicompartment approaches. However, these particular approaches have yet to be applied in clinical cohorts. The modeling of several diffusion parameters with interpretable biological meaning may offer the development of new, noninvasive biomarkers of pharmacoresistance in epilepsy. In the present study, we used FBI and FBWM to evaluate intra‐axonal and extra‐axonal diffusion properties of white matter tracts in patients with longstanding focal epilepsy. FBI/FBWM diffusion parameters were calculated along the length of 50 white matter tract bundles and statistically compared between patients with refractory epilepsy, nonrefractory epilepsy and controls. We report that patients with chronic epilepsy had a widespread distribution of extra‐axonal diffusivity relative to controls, particularly in circumscribed regions along white matter tracts projecting to cerebral cortex from thalamic, striatal, brainstem, and peduncular regions. Patients with refractory epilepsy had significantly greater markers of extra‐axonal diffusivity compared to those with nonrefractory epilepsy. The extra‐axonal diffusivity alterations in patients with epilepsy observed in the present study could be markers of neuroinflammatory processes or a reflection of reduced axonal density, both of which have been histologically demonstrated in focal epilepsy. FBI is a clinically feasible MRI approach that provides the basis for more interpretive conclusions about the microstructural environment of the brain and may represent a unique biomarker of pharmacoresistance in epilepsy. Bryant et al. used fiber ball imaging to measure intra‐axonal and extra‐axonal white matter diffusion in patients with longstanding focal epilepsy. It is reported that extra‐axonal diffusion is different between patients with refractory and nonrefractory epilepsy and may represent a novel imaging biomarker of pharmacoresistance.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.3
作者：
Assaf, Y;Freidlin, RZ;Basser, PJ
通讯作者：
Basser, PJ
影响因子：
11.2
作者：
Concha, L;Beaulieu, C;Gross, DW
通讯作者：
Gross, DW
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6.1
作者：
Amhaoul, Halima;Hamaide, Julie;Dedeurwaerdere, Stefanie
通讯作者：
Dedeurwaerdere, Stefanie
影响因子：
5.7
作者：
Andersson JLR;Sotiropoulos SN
通讯作者：
Sotiropoulos SN