Gene flow influences the genomic architecture of local adaptation in six riverine fish species
Gene flow influences the genomic architecture of local adaptation in six riverine fish species
复制标题
基因流影响六种河流鱼类局部适应的基因组结构
DOI：
10.1101/2021.05.18.444736
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
W. Larson
中科院分区：
文献类型：
--
作者：
Yue Shi;K. Bouska;G. McKinney;William K. Dokai;A. Bartels;M. McPhee;W. Larson
了解基因流如何影响适应分化对于预测适应反应是很重要的。理论研究认为，当基因流量大时，适应性基因聚集在较少的基因组区域，可以保护适应性等位基因不发生群体间重组，从而被选择，但很少有研究用实证数据验证这一假设。在这里，我们使用RADseq来生成来自美国密西西比河上游六个河段的六种鱼类的基因组数据，这些鱼类具有不同的生活史。然后，我们对基因组差异岛进行了基因组扫描，以检查适应性位点的分布，并调查这些位点是否在倒置中被发现。研究发现，不同物种间的基因流存在差异，且适应位点在基因流高的物种中聚集得更紧密。例如，总体FST最高（0.03 - 0.07）、因此基因流量最低的两个物种，几乎没有证据表明存在适应性位点簇，适应性位点在整个基因组中均匀分布。相比之下，FST最低（0.0004）的物种中几乎所有的适应性位点都在一个大的推测反转中被发现。另外2个基因流介于中间（FST ~ 0.004）的种属也表现出集群化的基因组结构，多数分化岛聚集在少数染色体上。这些结果提供了重要的经验证据，支持越来越多的本地适应集群结构与高基因流相关的假设。我们的研究利用了一个独特的系统，其中物种跨越了生活史的大梯度，以突出基因流在形成适应分化中的重要性。
Understanding how gene flow influences adaptive divergence is important for predicting adaptive responses. Theoretical studies suggest that when gene flow is high, clustering of adaptive genes in fewer genomic regions would protect adaptive alleles from among-population recombination and thus be selected for, but few studies have tested this hypothesis with empirical data. Here, we used RADseq to generate genomic data for six fish species with contrasting life histories from six reaches of the Upper Mississippi River System, USA. We then conducted genome scans for genomic islands of divergence to examine the distribution of adaptive loci and investigated whether these loci were found in inversions. We found that gene flow varied among species, and adaptive loci were clustered more tightly in species with higher gene flow. For example, the two species with the highest overall FST (0.03 - 0.07) and therefore lowest gene flow showed little evidence of clusters of adaptive loci, with adaptive loci spread uniformly across the genome. In contrast, nearly all adaptive loci in the species with the lowest FST (0.0004) were found in a single large putative inversion. Two other species with intermediate gene flow (FST ~ 0.004) also showed clustered genomic architectures, with most islands of divergence clustered on a few chromosomes. These results provide important empirical evidence to support the hypothesis that increasingly clustered architectures of local adaptation are associated with high gene flow. Our study utilized a unique system with species spanning a large gradient of life histories to highlight the importance of gene flow in shaping adaptive divergence.
影响因子：
5
作者：
Wilder AP;Palumbi SR;Conover DO;Therkildsen NO
通讯作者：
Therkildsen NO
DOI：
10.1146/annurev.ecolsys.39.110707.173532
发表时间：
2008-12-01
期刊：
Annual review of ecology, evolution, and systematics
影响因子：
--
作者：
Hoffmann AA;Rieseberg LH
通讯作者：
Rieseberg LH
影响因子：
9.8
作者：
Purcell, Shaun;Neale, Benjamin;Sham, Pak C.
通讯作者：
Sham, Pak C.