Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis.
Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis.
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DOI：
10.1038/mp.2014.111
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发表时间：
2014-11
影响因子：
11
通讯作者：
Sadeh, N.
中科院分区：
文献类型：
--
作者：
Miller, M. W.;Sadeh, N.
创伤后应激障碍（PTSD）与各种年龄相关疾病和神经变性的风险升高有关。在本文中，我们回顾了与慢性创伤后应激障碍（PTSD）构成一种持续的生活应激形式，增强氧化应激（OXS）和加速细胞衰老的假设相关的证据。本文综述了心理应激对OXS影响的实证研究，讨论了PTSD的压力持续特征，并确定了PTSD促进OXS和加速衰老的机制。我们回顾了oxs相关基因的研究，以及它们在调节PTSD对神经完整性的影响中可能发挥的作用，最后讨论了抗氧化治疗和PTSD加速衰老生物标志物的未来研究方向。
Posttraumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellular aging. We provide an overview of empirical studies that have examined the effects of psychological stress on OXS, discuss the stress-perpetuating characteristics of PTSD, and then identify mechanisms by which PTSD might promote OXS and accelerated aging. We review studies on OXS-related genes and the role that they may play in moderating the effects of PTSD on neural integrity and conclude with a discussion of directions for future research on antioxidant treatments and biomarkers of accelerated aging in PTSD.
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影响因子：
3.1
作者：
Cohen, L;Marshall, GD;Wei, QY
通讯作者：
Wei, QY
影响因子：
4.6
作者：
Andrews, Bernice;Brewin, Chris R.;Hejdenberg, Jennie
通讯作者：
Hejdenberg, Jennie
影响因子：
3.7
作者：
Aschbacher, Kirstin;O'Donovan, Aoife;Wolkowitz, Owen M.;Dhabhar, Firdaus S.;Su, Yali;Epel, Elissa
通讯作者：
Epel, Elissa
影响因子：
3.3
作者：
Afari N;Ahumada SM;Wright LJ;Mostoufi S;Golnari G;Reis V;Cuneo JG
通讯作者：
Cuneo JG
影响因子：
15.9
作者：
Distler, Margaret G.;Plant, Leigh D.;Palmer, Abraham A.
通讯作者：
Palmer, Abraham A.