Inflammatory Burden and Immunomodulative Therapeutics of Cardiovascular Diseases.
Inflammatory Burden and Immunomodulative Therapeutics of Cardiovascular Diseases.
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DOI：
10.3390/ijms23020804
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发表时间：
2022-01-12
影响因子：
5.6
通讯作者：
Huang CC
中科院分区：
文献类型：
--
作者：
Kao TW;Huang CC
表型心血管疾病和认识异质性是关键在当代时代。除了传统的危险因素外，越来越多的证据表明，高炎症负担已成为调节心血管疾病（包括动脉粥样硬化和心肌梗死）发病和进展的关键特征。为了从机制上阐明这种相关性，下游的toll样受体、核苷酸寡聚结构域样受体、白细胞介素、肿瘤坏死因子和相应的细胞因子的信号通路被认为是发挥炎症作用的中心机制。其他显著的辅助因子包括氧化应激和继发性铁下垂。这些分子的发现推动了制药的进步。他汀类药物不仅可以降低胆固醇水平，还可以减轻炎症，从而对心血管有益。秋水仙碱作为一种免疫调节剂与冠状动脉介入治疗联合使用。新的白细胞介素-1β和- 6拮抗剂在最近的试验中也显示出有希望的心脏益处。此外，对肠道微生物群和相关代谢物的操纵是为了对抗炎症相关的心血管病理生理。其中建立了肠-心-肾轴来解释相互关系。从未来的角度来看，人工智能与机器学习的结合可以更好地阐明微生物组的测序和数据挖掘。全面了解肠道微生物群及其心血管影响之间的相互作用将有助于确定未来的治疗靶点，为心血管疾病患者提供整体护理。
Phenotyping cardiovascular illness and recognising heterogeneities within are pivotal in the contemporary era. Besides traditional risk factors, accumulated evidence suggested that a high inflammatory burden has emerged as a key characteristic modulating both the pathogenesis and progression of cardiovascular diseases, inclusive of atherosclerosis and myocardial infarction. To mechanistically elucidate the correlation, signalling pathways downstream to Toll-like receptors, nucleotide oligomerisation domain-like receptors, interleukins, tumour necrosis factor, and corresponding cytokines were raised as central mechanisms exerting the effect of inflammation. Other remarkable adjuvant factors include oxidative stress and secondary ferroptosis. These molecular discoveries have propelled pharmaceutical advancements. Statin was suggested to confer cardiovascular benefits not only by lowering cholesterol levels but also by attenuating inflammation. Colchicine was repurposed as an immunomodulator co-administered with coronary intervention. Novel interleukin-1β and −6 antagonists exhibited promising cardiac benefits in the recent trials as well. Moreover, manipulation of gut microbiota and associated metabolites was addressed to antagonise inflammation-related cardiovascular pathophysiology. The gut-cardio-renal axis was therein established to explain the mutual interrelationship. As for future perspectives, artificial intelligence in conjunction with machine learning could better elucidate the sequencing of the microbiome and data mining. Comprehensively understanding the interplay between the gut microbiome and its cardiovascular impact will help identify future therapeutic targets, affording holistic care for patients with cardiovascular diseases.
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影响因子：
--
作者：
Guo S;Huang Z;Liu X;Zhang J;Ye P;Wu C;Lu S;Jia S;Zhang X;Chen X;Wang M;Wu J
通讯作者：
Wu J
影响因子：
3.5
作者：
Iyer RP;Patterson NL;Zouein FA;Ma Y;Dive V;de Castro Brás LE;Lindsey ML
通讯作者：
Lindsey ML
影响因子：
120.7
作者：
de Lemos, JA;Blazing, MA;Braunwald, E
通讯作者：
Braunwald, E
单核细胞向巨噬细胞分化：复杂细胞外基质的合成和分泌。
DOI：
10.1074/jbc.m111.324988
发表时间：
2012-04-20
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chang MY;Chan CK;Braun KR;Green PS;O'Brien KD;Chait A;Day AJ;Wight TN
通讯作者：
Wight TN
影响因子：
6.9
作者：
Daseke, Michael J., II;Tenkorang, Mavis A. A.;Lindsey, Merry L.
通讯作者：
Lindsey, Merry L.