Transformation of adaptation and gain rescaling along the whisker sensory pathway.
Transformation of adaptation and gain rescaling along the whisker sensory pathway.
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胡须感觉通路上的适应转换和增益重排
DOI：
10.1371/journal.pone.0082418
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Petersen RS
中科院分区：
文献类型：
--
作者：
Maravall M;Alenda A;Bale MR;Petersen RS
所有感觉系统中的神经元都有一种非凡的能力，可以使它们的灵敏度适应它们所调谐的感觉信号的统计结构。在桶状皮层中，放电率与须状刺激的方差相适应，神经元的灵敏度（增益）与刺激的标准差成反比。为了确定适应性是如何通过上升门神经通路转变的，我们测量了在皮质下阶段的第一个和最后一个单元，三叉神经节（TRG）和腹侧后内侧丘脑核（VPM），对尿素麻醉大鼠的可控须刺激的反应。我们使用滤过的白噪声刺激在低方差和高方差时期之间切换来探索适应性。我们发现TRG和VPM神经元的放电速率都适应刺激的变化。通过将每个单元的响应拟合到线性-非线性-泊松模型中，我们测试了适应性是否改变了特征选择性和/或敏感性。我们发现，尽管特征选择性不受刺激方差的影响，但单元的敏感性往往表现出显著的变化。这些敏感性变化的程度沿着从TRG到桶状皮质的通路系统地增加。然而，在不同的单位中，特别是在VPM中，存在明显的差异。总之，在须系统中，皮层下神经元的适应特性是惊人的多样化。这种多样性的意义可能在于，它有助于丰富的种群代表的须动态。
Neurons in all sensory systems have a remarkable ability to adapt their sensitivity to the statistical structure of the sensory signals to which they are tuned. In the barrel cortex, firing rate adapts to the variance of a whisker stimulus and neuronal sensitivity (gain) adjusts in inverse proportion to the stimulus standard deviation. To determine how adaptation might be transformed across the ascending lemniscal pathway, we measured the responses of single units in the first and last subcortical stages, the trigeminal ganglion (TRG) and ventral posterior medial thalamic nucleus (VPM), to controlled whisker stimulation in urethane-anesthetized rats. We probed adaptation using a filtered white noise stimulus that switched between low- and high-variance epochs. We found that the firing rate of both TRG and VPM neurons adapted to stimulus variance. By fitting the responses of each unit to a Linear-Nonlinear-Poisson model, we tested whether adaptation changed feature selectivity and/or sensitivity. We found that, whereas feature selectivity was unaffected by stimulus variance, units often exhibited a marked change in sensitivity. The extent of these sensitivity changes increased systematically along the pathway from TRG to barrel cortex. However, there was marked variability across units, especially in VPM. In sum, in the whisker system, the adaptation properties of subcortical neurons are surprisingly diverse. The significance of this diversity may be that it contributes to a rich population representation of whisker dynamics.
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影响因子：
3.4
作者：
Garcia-Lazaro, J. A.;Ho, S. S. M.;Schnupp, J. W. H.
通讯作者：
Schnupp, J. W. H.
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Lampl, Ilan
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通讯作者：
Haidarliu, S
影响因子：
25
作者：
Dean, I;Harper, NS;McAlpine, D
通讯作者：
McAlpine, D